Method and System for Providing Calibration of an Analyte Sensor in an Analyte Monitoring System

Abstract

Method and apparatus for providing calibration of analyte sensor including applying a control signal, detecting a measured response to the control signal, determining a variance in the detected measured response, and estimating a sensor sensitivity based on the variance in the detected measured response is provided

1 . (canceled) 
     
     
         2 . A method for determining whether an analyte sensor system is functioning properly, the method comprising:
 applying a stimulus signal to the analyte sensor;   measuring a response to the stimulus signal;   estimating a value of a sensor property based on the signal response;   correlating the sensor property value with a predetermined relationship of the sensor property and a predetermined sensor sensitivity profile; and   initiating an error routine if the correlation does not exceed a predetermined correlation threshold.   
     
     
         3 . The method of  claim 2 , wherein correlating includes performing a data association analysis. 
     
     
         4 . The method of  claim 2 , wherein the error routine comprises displaying a message to a user indicating that the analyte sensor is not functioning properly. 
     
     
         5 . The method of  claim 2 , wherein the sensor property is an impedance of the sensor membrane. 
     
     
         6 . A sensor system configured to implement the method of  claim 2 . 
     
     
         7 . The sensor system of  claim 6 , wherein the sensor system comprises instructions stored in computer memory, wherein the instructions, when executed by one or more processors of the sensor system, cause the sensor system to implement the method of  claim 2 . 
     
     
         8 . A method for determining membrane damage of an analyte sensor using a sensor system, comprising:
 applying a stimulus signal to an analyte sensor;   measuring a response to the stimulus signal;   calculating, using sensor electronics, an impedance based on the signal response;   determining, using the sensor electronics, whether the impedance falls within a predefined level corresponding to membrane damage; and   initiating, using the sensor electronics, an error routine if the impedance exceeds the predefined level.   
     
     
         9 . The method of  claim 8 , wherein the error routine includes triggering one or more of an audible alarm and a visual alarm on a display screen. 
     
     
         10 . The method of  claim 8 , wherein the stimulus signal has a predetermined frequency. 
     
     
         11 . The method of  claim 8 , wherein the stimulus signal comprises a spectrum of frequencies. 
     
     
         12 . The method of  claim 8 , wherein the calculated impedance comprises a magnitude value and a phase value, and wherein the determination comprises comparing the impedance magnitude value to a predefined impedance magnitude threshold and the phase value to a predefined phase threshold. 
     
     
         13 . The method of  claim 8 , wherein the calculated impedance is a complex impedance value. 
     
     
         14 . A sensor system configured to implement the method of  claim 8 . 
     
     
         15 . The sensor system of  claim 14 , wherein the sensor system comprises instructions stored in computer memory, wherein the instructions, when executed by one or more processors of the sensor system, cause the sensor system to implement the method of  claim 8 . 
     
     
         16 . A method for determining a property of a continuous analyte sensor, the method comprising:
 applying a stimulus signal to a first analyte sensor having a first working electrode and a first reference electrode;   measuring a signal response of the stimulus signal using a second analyte sensor having a second working electrode and a second reference electrode; and   determining a property of the first sensor by correlating the response to a predetermined relationship.   
     
     
         17 . The method of  claim 16 , further comprising generating sensor data by applying a bias voltage to the first working electrode and measuring a response to the bias voltage. 
     
     
         18 . The method of  claim 17 , further comprising calibrating the sensor data using the determined property. 
     
     
         19 . The method of  claim 16 , wherein the determined property is one of an impedance and a temperature. 
     
     
         20 . The method of  claim 16 , further comprising determining sensor membrane damage using the determined property. 
     
     
         21 . A sensor system configured to implement the method of  claim 16 . 
     
     
         22 . The sensor system of  claim 21 , wherein the sensor system comprises instructions stored in computer memory, wherein the instructions, when executed by one or more processors of the sensor system, cause the sensor system to implement the method of  claim 16 . 
     
     
         23 . A method for calibrating an analyte sensor, the method comprising:
 applying a predetermined signal to an analyte sensor;   measuring a response to the applied signal;   determining, using sensor electronics, a change in impedance associated with a membrane of the analyte sensor based on the measured response;   calculating a sensitivity change of the analyte sensor based on the determined impedance;   calculating a corrected sensitivity based on the calculated sensitivity change and a previously used sensitivity of the analyte sensor; and   generating estimated analyte values using the corrected sensitivity.   
     
     
         24 . The method of  claim 23 , wherein calculating the sensitivity change comprises applying a non-linear compensation function. 
     
     
         25 . A sensor system configured to implement the method of  claim 23 . 
     
     
         26 . The sensor system of  claim 25 , wherein the sensor system comprises instructions stored in computer memory, wherein the instructions, when executed by one or more processors of the sensor system, cause the sensor system to implement the method of  claim 23 .