Organ-specific gene, method for identifying the same and use thereof

Abstract

The present invention provides a method of extracting an organ- or tissue-specific highly expressed gene, including: (1) a step for measuring expression level of a specified gene group for each organ or tissue in 2 or more individuals, (2) a step for acquiring (a) a minimum value of expression levels in a particular organ or tissue in all individuals, and (b) a maximum value of expression levels in other organs and tissues in all individuals, for each gene, and (3) a step for extracting the gene as a gene highly expressed specifically in the particular organ or tissue if the above-described (a)/(b) ratio is larger than 1. By the present invention, truly organ- or tissue-specific genes are extracted.

1 - 23 . (canceled) 
     
     
         24 . An analytical tool of any one of the following (1) to (18):
 (1) an analytical tool for the expression of mouse fat tissue specific genes, comprising 1 or more selected from among 35 kinds of nucleic acids comprising each base sequence shown by SEQ ID NO:n1 (n1 is an integer of 1 to 35) or a partial sequence thereof;   (2) an analytical tool for the expression of mouse urinary bladder specific genes, comprising 1 or more selected from among 36 kinds of nucleic acids comprising each base sequence shown by SEQ ID NO:n2 (n2 is an integer of 36 to 71) or a partial sequence thereof;   (3) an analytical tool for the expression of mouse blood specific genes, comprising 1 or more selected from among 431 kinds of nucleic acids comprising each base sequence shown by SEQ ID NO:n3 (n3 is an integer of 72 to 502) or a partial sequence thereof;   (4) an analytical tool for the expression of mouse bone specific genes, comprising 1 or more selected from among 6 kinds of nucleic acids comprising each base sequence shown by SEQ ID NO:n4 (n4 is an integer of 503 to 508) or a partial sequence thereof;   (5) an analytical tool for the expression of mouse brain specific genes, comprising 1 or more selected from among 246 kinds of nucleic acids comprising each base sequence shown by SEQ ID NO:n5 (n5 is an integer of 509 to 754) or a partial sequence thereof;   (6) an analytical tool for the expression of mouse mammary gland specific genes, comprising 1 or more selected from among 17 kinds of nucleic acids comprising each base sequence shown by SEQ ID NO:n6 (n6 is an integer of 755 to 771) or a partial sequence thereof;   (7) an analytical tool for the expression of mouse colon specific genes, comprising 1 or more selected from among 52 kinds of nucleic acids comprising each base sequence shown by SEQ ID NO:n7 (n7 is an integer of 772 to 823) or a partial sequence thereof;   (8) an analytical tool for the expression of mouse esophagus specific genes, comprising a nucleic acid comprising the base sequence shown by SEQ ID NO:824 or a partial sequence thereof, and/or a nucleic acid comprising the base sequence shown by SEQ ID NO:825 or a partial sequence thereof;   (9) an analytical tool for the expression of mouse heart specific genes, comprising 1 or more selected from among 23 kinds of nucleic acids comprising each base sequence shown by SEQ ID NO:n9 (n9 is an integer of 826 to 848) or a partial sequence thereof;   (10) an analytical tool for the expression of mouse liver specific genes, comprising 1 or more selected from among 144 kinds of nucleic acids comprising each base sequence shown by SEQ ID NO:n10 (n10 is an integer of 849 to 992) or a partial sequence thereof;   (11) an analytical tool for the expression of mouse lung specific genes, comprising 1 or more selected from among 143 kinds of nucleic acids comprising each base sequence shown by SEQ ID NO:n11 (n11 is an integer of 993 to 1135) or a partial sequence thereof;   (12) an analytical tool for the expression of mouse pancreas specific genes, comprising 1 or more selected from among 2970 kinds of nucleic acids comprising each base sequence shown by SEQ ID NO:n12 (n12 is an integer of 1136 to 4105) or a partial sequence thereof;   (13) an analytical tool for the expression of mouse spleen specific genes, comprising 1 or more selected from among 195 kinds of nucleic acids comprising each base sequence shown by SEQ ID NO:n13 (n13 is an integer of 4106 to 4300) or a partial sequence thereof;   (14) an analytical tool for the expression of mouse stomach specific genes, comprising 1 or more selected from among 29 kinds of nucleic acids comprising each base sequence shown by SEQ ID NO:n14 (n14 is an integer of 4301 to 4329) or a partial sequence thereof;   (15) an analytical tool for the expression of mouse testis specific genes, comprising 1 or more selected from among 4669 kinds of nucleic acids comprising each base sequence shown by SEQ ID NO:n15 (n15 is an integer of 4330 to 8998) or a partial sequence thereof;   (16) an analytical tool for the expression of mouse thymus specific genes, comprising 1 or more selected from among 141 kinds of nucleic acids comprising each base sequence shown by SEQ ID NO:n16 (n16 is an integer of 8999 to 9139) or a partial sequence thereof;   (17) an analytical tool for the expression of mouse kidney specific genes, comprising 1 or more selected from among 66 kinds of nucleic acids comprising each base sequence shown by SEQ ID NO:n17 (n17 is an integer of 9140 to 9205) or a partial sequence thereof; and   (18) an analytical tool for the expression of mouse pancreas and prostate specific genes, comprising a nucleic acid comprising the base sequence shown by SEQ ID NO:9206 or a partial sequence thereof.