Combination Drug Containing Probucol and a Tetrazolyalkoxy-Dihydrocarbostyril Derivative With Superoxide Supressant Effects

Abstract

This invention relates to a combination drug comprising a combination of a tetrazolylalkoxy-dihydrocarbostyril derivative of the formula: wherein R is cycloalkyl, A is lower alkylene, and the bond between 3- and 4-positions of carbostyril nucleus is single bond or double bond, or a salt thereof and Probucol, which is useful for preventing and treating cerebral infarction including acute cerebral infarction and chronic cerebral infarction, arteriosclerosis, renal diseases (e.g. diabetic nephropathy, renal failure, nephritis), and diabetes owing to synergistic superoxide suppressant effects of the combination.

1 - 30 . (canceled) 
     
     
         31 . A method for suppressing superoxide in a patient who has cerebral infarction, which comprises administering a combination of an effective amount of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydrocarbostyril or a salt thereof and an effective amount of Probucol to the patient. 
     
     
         32 . A method for preventing and treating cerebral infarction, which comprises administering a combination of an effective amount of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydrocarbostyril or a salt thereof and an effective amount of Probucol to a subject in need. 
     
     
         33 . A method for suppressing superoxide in a patient who has renal diseases, which comprises administering a combination of an effective amount of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydrocarbostyril or a salt thereof and an effective amount of Probucol to the patient. 
     
     
         34 . A method for preventing and treating renal diseases, which comprises administering a combination of an effective amount of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydrocarbostyril or a salt thereof and an effective amount of Probucol to a subject in need. 
     
     
         35 . A method for suppressing superoxide in a patient who has diabetes, which comprises administering a combination of an effective amount of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydrocarbostyril or a salt thereof and an effective amount of Probucol to the patient. 
     
     
         36 . A method for preventing and treating diabetes, which comprises administering a combination of an effective amount of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydrocarbostyril or a salt thereof and an effective amount of Probucol to a subject in need.