Glycosaminoglycan Composition and Method for Treatment and Prevention of Interstitial Cystitis

Abstract

The invention provides compositions and methods useful for the treatment and/or prevention of interstitial cystitis and/or a related urinary tract condition in man or in animals. Specifically, provided are compositions specially formulated for direct instillation into the bladder and/or parenteral use in the treatment and/or prevention of interstitial cystitis. Compositions adapted for direct instillation into the bladder and/or for systemic administration are provided comprised of therapeutic amounts of: chondroitin sulfate in combination with hyaluronan (hyaluronic acid) are provided. Compositions adapted for direct instillation into the bladder and/or for systemic administration are also provided comprised of therapeutic amounts of: chondroitin sulfate, hyaluronan (hyaluronic acid) and N-acetyl D-glucosamine.

What is claimed is: 
     
         1 . A composition formulated for direct bladder instillation and for treatment of interstitial cystitis or a related urinary tract condition in man or in animals consisting essentially of an effective amount of chondroitin sulfate and hyaluronan. 
     
     
         2 . The composition of  claim 1 , wherein said chondroitin sulfate is CS4 chondroitin sulfate. 
     
     
         3 . The composition of  claim 1 , wherein said chondroitin sulfate is CS6 chondroitin sulfate. 
     
     
         4 . The composition of  claim 1 , wherein said chondroitin sulfate is a mixture of CS4 chondroitin sulfate and CS6 chondroitin sulfate. 
     
     
         5 . The composition of  claim 1 , where said effective amount of chondroitin sulfate is between about 0.5 grams to about 1.5 grams per unit dose of the composition. 
     
     
         6 . The composition of  claim 1 , where said effective amount of hyaluronan is about 10 mg to about 50 mg of hyaluronan per unit dose of the composition per unit dose of the composition. 
     
     
         7 . The composition of  claim 1 , further comprises one or more excipients to facilitate the treatment. 
     
     
         8 . The composition of  claim 1 , wherein said composition is a sterile solution. 
     
     
         9 . The composition of  claim 1 , wherein said composition is a sterile suspension.