Implant and method for manufacturing same

Abstract

The present invention relates to a method for manufacturing an implant, in particular an intraluminal endoprosthesis, having a body containing metallic material, preferably iron. The following manufacturing method is provided for promotion of the anti-inflammatory effect of the implant: (i) providing the body of the implant; (ii) producing an at least partially closed pore structure in a portion of the structure of the implant body close to the surface; and (iii) incorporating NO x into the cavities of the pore structure. Also described is an implant manufactured in this manner.

1 . An implant, optionally an intraluminal endoprosthesis, having a body containing metallic material, optionally iron, obtainable by:
 i) providing the body of the implant;   ii) producing an at least partially closed pore structure in a portion of the structure of the implant body close to the surface, comprising a reducing step followed by an annealing step in an oxidizing atmosphere, wherein the pore structure has a diameter of less than 1 μm; and   iii) incorporating NO x  into the cavities of the pore structure.   
     
     
         2 . An implant, optionally an intraluminal endoprosthesis, having a body containing metallic material, optionally iron, wherein the implant body has an at least partially closed pore structure in a portion of its structure close to the surface which includes NO x  in its cavities. 
     
     
         3 . The implant according to  claim 2 , wherein the pores of the pore structure have a maximum diameter of approximately 1 μm. 
     
     
         4 . The implant according to  claim 2 , wherein the cavities of the pore structure accommodating the NO x  extend to a maximum depth (T) of approximately 15 μm measured from the surface of the implant body. 
     
     
         5 . The implant according to  claim 4 , wherein the cavities of the pore structure accommodating the NO x  extend to a maximum depth (T) of between approximately 10 μm to approximately 15 μm, measured from the surface of the implant body. 
     
     
         6 . The implant according to  claim 2 , wherein the concentration of NO x  in the structure of the implant body close to the surface is approximately 10% by volume. 
     
     
         7 . The implant according to  claim 2 , wherein the surface of the implant body has a coating, at least in places, which comprises a polymer, optionally a polymer from the group consisting of magnesium stearate, parylene, and a pharmaceutically active substance.