Compositions comprising tramadol and celecoxib in the treatment of pain

Abstract

The present invention relates to pharmaceutical compositions comprising tramadol and celecoxib and their uses as medicaments or analgesics, more particularly for the treatment of severe to moderate pain with an inflammation component.

1 . A pharmaceutical composition comprising a synergistic combination of (rac)-tramadol.HCl and celecoxib or a pharmaceutically acceptable salt or hydrate thereof, wherein the molecular ratio of the (rac)-tramadol.HCl to the celecoxib is a molar ratio of from about 1:1 to about 1:3 or from about 1:1 to about 3:1. 
     
     
         2 . A pharmaceutical composition according to  claim 1 , wherein the molecular ratio of the (rac)-tramadol.HCl to the celecoxib is a molar ratio of about 3:1. 
     
     
         3 . A pharmaceutical composition according to  claim 1 , wherein the molecular ratio of the (rac)-tramadol.HCl to the celecoxib is a molar ratio of about 1:3. 
     
     
         4 . A pharmaceutical composition according to  claim 1 , wherein the molecular ratio of the (rac)-tramadol.HCl to the celecoxib is a molar ratio of about 1:1. 
     
     
         5 . A pharmaceutical composition according to  claim 1 , wherein the celecoxib is in neutral form. 
     
     
         6 . A pharmaceutical composition according to  claim 1 , wherein the composition is a liquid composition. 
     
     
         7 . A method for the treatment of pain comprising administering to a subject in need thereof a therapeutically effective amount of at least one pharmaceutical composition according to  claim 1 . 
     
     
         8 . A method according to  claim 7 , wherein said pain is selected from acute pain, chronic pain, neuropathic pain, nociceptive pain, mild and severe to moderate pain, hyperalgesia, pain related to central sensitization, allodynia or cancer pain, diabetic neuropathy, diabetic peripheral neuropathy, osteoarthritis, fibromyalgia, rheumatoid arthritis, ankylosing spondylitis, frozen shoulder and sciatica.