Treatment of cancer with complex organic-inorganic pigment compositions

Abstract

The present invention includes compositions and methods for treating disorders of the skin or mucosa resulting from cancer therapies comprising: identifying a patient receiving cancer treatment; and administering to said patient an effective dose of a treated organic/inorganic complex material with an organic dye molecule or derivative thereof, in a pharmaceutically acceptable carrier.

What is claimed is: 
     
         1 . A method of treating cancer comprising contacting the cancer with a composition comprising a therapeutically effective amount of a treated organic/inorganic complex material comprising an organic dye molecule or derivative thereof in an inorganic material, in a pharmaceutically acceptable carrier. 
     
     
         2 . The method of  claim 1 , wherein the effective amount is 10 to 3,000 mg/kg. 
     
     
         3 . The method of  claim 1 , wherein the organic dye molecule comprises Maya blue dye or derivatives thereof. 
     
     
         4 . The method of  claim 1 , further comprising the step of micronizing the composition. 
     
     
         5 . The method of  claim 1 , further comprising the step of adapting the composition for administration in an amount of from 10 mg/kg body weight to 10,000 mg/kg body weight. 
     
     
         6 . The method of  claim 1 , further comprising the step of adapting the composition for administration orally, enterically, intravenously, peritoneally, parenterally or subcutaneously. 
     
     
         7 . The method of  claim 1 , wherein the cancer is at least one of carcinoma, leukemia, melanoma, stomach cancer, colon cancer, breast cancer, lung cancer, brain cancer, pancreatic cancer, ovarian cancer, head and neck cancer, liver cancer, prostate cancer, metastatic cancer or a solid tumor. 
     
     
         8 . The method of  claim 1 , further comprising adding an effective amount of a second chemotherapeutic agent to the composition. 
     
     
         9 . A method for treating an animal having a tumor comprising administering to the animal a therapeutically effective amount of a treated organic/inorganic complex material with a Maya blue dye molecule or derivatives thereof, in a pharmaceutically acceptable carrier to induce necrosis in at least a portion of the tumor, induces tumor regression or induces tumor remission. 
     
     
         10 . The method of  claim 9 , wherein the effective amount is 10 to 3,000 mg/kg. 
     
     
         11 . The method of  claim 9 , wherein the organic dye molecule comprises Maya blue dye, or derivatives thereof in the form of a prodrug thereof. 
     
     
         12 . The method of  claim 9 , further comprising the step of micronizing the composition. 
     
     
         13 . The method of  claim 9 , further comprising the step of adapting the composition for administration in an amount of from 10 mg/kg body weight to 10,000 mg/kg body weight. 
     
     
         14 . The method of  claim 9 , further comprising the step of adapting the composition for administration orally, enterically, intravenously, peritoneally, parenterally or subcutaneously. 
     
     
         15 . The method of  claim 9 , wherein the tumor is a carcinoma, leukemia, melanoma, stomach cancer, colon cancer, breast cancer, lung cancer, brain cancer, pancreatic cancer, ovarian cancer, head and neck cancer, liver cancer, prostate cancer, metastatic cancer or a solid tumor. 
     
     
         16 . The method of  claim 9 , further comprising adding an effective amount of a second chemotherapeutic agent to the composition. 
     
     
         17 . A method of treating a cancer comprising administering to a subject in need thereof an effective amount of a composition comprising a therapeutically effective amount of a treated organic/inorganic complex material with an organic dye molecule selected from Maya Blue dye or derivative thereof, in a pharmaceutically acceptable carrier, wherein said cancer is selected from the group consisting of a stomach, color or breast cancer. 
     
     
         18 . A method for treating disorders of the skin or mucosa resulting from cancer therapies comprising:
 identifying a patient in need of cancer treatment; and   administering to the patient an effective dose of an organic/inorganic complex of Maya Blue dye or derivative thereof and an inorganic fibrous clay material in a pharmaceutically acceptable carrier, wherein the Maya blue dye and the inorganic fibrous clay material are bonded by heating the Maya blue dye and the inorganic fibrous clay material or exposing them to UV light to enhance a cancer suppression ability of the Maya blue dye and the inorganic fibrous clay material.   
     
     
         19 . A method of treating cancer comprising contacting the cancer with a composition comprising a therapeutically effective amount of a treated organic/inorganic complex material comprising a Maya blue dye and an inorganic fibrous clay material, in a pharmaceutically acceptable carrier, in which the Maya blue dye and the inorganic fibrous clay material are connected by a stabilized organic and inorganic bond formed by heating the Maya blue dye and the inorganic fibrous clay material or exposing them to UV light such that the molecular properties of the Maya blue dye and the inorganic fibrous clay material are changed to enhance a cancer suppression ability of the composition. 
     
     
         20 . The method of  claim 19 , wherein the cancer is selected from at least one of a carcinoma, leukemia, melanoma, stomach cancer, colon cancer, breast cancer, lung cancer, brain cancer, pancreatic cancer, ovarian cancer, head and neck cancer, liver cancer, prostate cancer, metastatic cancer or a solid tumor. 
     
     
         21 . A method for treating an animal having a cancer, comprising administering to the animal a therapeutically effective amount of a treated organic/inorganic complex material that comprises a Maya blue dye and an inorganic fibrous clay material in a pharmaceutically acceptable carrier to induce necrosis in at least a portion of the cancer, to induce cancer regression or to induce cancer remission, in which the Maya blue dye and the inorganic fibrous clay material are connected by a stabilized organic and inorganic bond formed by heating the Maya blue dye and the inorganic fibrous clay material or exposing them to UV light such that the molecular properties of the Maya blue dye and the inorganic fibrous clay material are changed to enhance a cancer suppression ability of the composition. 
     
     
         22 . The method of  claim 21 , wherein the cancer is a carcinoma, leukemia, melanoma, stomach cancer, colon cancer, breast cancer, lung cancer, brain cancer, pancreatic cancer, ovarian cancer, head and neck cancer, liver cancer, prostate cancer, metastatic cancer or a solid tumor.