Composition for accelerated production of collagen

Abstract

Here the inventors provide a composition for topical application to the skin of animal comprising stearidonic acid in combination with one or more octadecatrienoic acids (CODTAs). Preferably the composition comprises echium oil as a source of the stearidonic acid, and a plant lipid as a source of octadcatrienoic acid, such as borage ( Borago officinalis ), wheat germ oil ( Triticum vulgare ), rosehip oil (refined; Rosa mosqueta ), jacaranda oil ( Jacandra mimosa folia ), and/or calendula oil ( Calendula officinalis ). The composition of the invention increases collagen I secretion and thus has particular utility for promoting collagen production in skin.

1 . A composition for topical application to the skin of animal comprising  echium  oil containing stearidonic acid in combination with one or more of  jacaranda  oil and  calendula  oil containing one or more octadecatrienoic acids, wherein the composition is effective to increase collagen I production in skin. 
     
     
         2 . The composition of  claim 1  wherein the  echium  oil is extracted from  Echium plantagineum  L. 
     
     
         3 . The composition of  claim 1  wherein the one or more octadecatrienoic acids is Calendic acid and/or Jacaric acid. 
     
     
         4 . The composition of  claim 1  wherein the ratio of  echium  oil to  jacaranda  oil and/or  calendula  oil is in the range of 10:1 to 1:10. 
     
     
         5 . The composition of  claim 1  wherein the  echium  oil and the one or more of  jacaranda  oil and  calendula  oil are extracted from plant seed using a supercritical carbon dioxide extraction process. 
     
     
         6 . A pharmaceutical composition comprising a composition according to  claim 1  and a pharmaceutically acceptable excipient. 
     
     
         7 . A method of treating skin comprising topically applying a composition or a pharmaceutical composition according to  claim 1  to the skin. 
     
     
         8 . A composition or a pharmaceutical composition according to  claim 1  to the skin for use as a medicament for increasing collagen production in skin. 
     
     
         9 . A composition for topical application to the skin of an animal comprising  echium  oil containing stearidonic acid in combination with one or more plant lipids containing octadecatrienoic acids selected from calendic acid and jacaric acid, wherein the one or more plant lipids are selected from the group consisting of  jacaranda  oil and  calendula  oil, wherein the composition is effective to increase collagen I production in skin. 
     
     
         10 . The composition of  claim 1  wherein the ratio of  echium  oil to  jacaranda  oil and/or  calendula  oil is 1:5. 
     
     
         11 . The composition of  claim 1  wherein the ratio of  echium  oil to  jacaranda  oil and/or  calendula  oil is 1:3. 
     
     
         12 . The composition of  claim 1  wherein the ratio of  echium  oil to  jacaranda  oil and/or  calendula  oil is 1:1. 
     
     
         13 . The composition of  claim 1  wherein the ratio of  echium  oil to  jacaranda  oil and/or  calendula  oil is 3:1. 
     
     
         14 . The composition of  claim 1  wherein the ratio of  echium  oil to  jacaranda  oil and/or  calendula  oil is 5:1.