Use of allopurinol for the treatment of palmar plantar erythrodysesthesia

Abstract

Use of allopurinol or a pharmaceutically acceptable salt thereof for the treatment or prevention of palmar plantar erythrodysesthesia induced by chemotherapy. The allopurinol or its salt is administered topically to the affected areas, palms and soles, preferably in the form of a cream.

1 - 13 . (canceled) 
     
     
         14 . A method for treating or preventing palmar plantar erythrodysesthesia (PPE) induced by fluoropyrimidine chemotherapy or by pegylated doxorubicin in a patient in need thereof comprising administering to the patient a medicament having an amount of allopurinol or a pharmaceutically acceptable salt thereof which is therapeutically effective to treat or prevent PPE. 
     
     
         15 . A pharmaceutical composition for the topical administration to the skin, comprising from 1-10% by weight of the total composition of allopurinol or a pharmaceutically acceptable salt thereof, wherein the pharmaceutical composition is formulated to topical administration to the skin, and is free of methylsulphonylmethane or cetomacrogol.