Actinobacillus suis antigens

Abstract

The invention provides immunogenic compositions useful for inhibiting, treating, protecting, or preventing infection by Actinobacillus suis . These immunogenic compositions are demonstrated to usefully stimulate immunogenic responses in treated pigs. Some vaccines stimulated reactions sufficient to be protective against A. suis . In addition, the invention provides kits comprising the immunogenic compositions; as well as, methods of using the compositions and kits.

What is claimed is: 
     
         1 . A method of diagnosing  Actinobacillus suis  infection in a subject, comprising
 a) providing a filtered supernatant prepared by growing an  A. suis  culture to between 0.650 OD 650  and 0.850 OD 650 , collecting supernatant from the culture, and filtering the supernatant;   b) contacting the filtered supernatant with a sample obtained from the subject; and   c) identifying the subject as having an  A. suis  infection if an antibody capable of binding a component in the filtered supernatant is detected in the sample.   
     
     
         2 . The method of  claim 1 , wherein the binding is detected using a second antibody capable of binding the antibody in the sample.