Implantation Compositions for Use in Tissue Augmentation

Abstract

A composition of matter and method for preparation of a tissue augmentation material. A polysaccharide gel composition is prepared with rheological properties selected for a particular selected application. The method includes preparing a polymeric polysaccharide in a buffer to create a polymer solution or gel suspending properties in the gel and selecting a rheology profile for the desired tissue region.

What is claimed is: 
     
         1 . A method of preparing a tissue implant comprising:
 (i) preparing an aqueous carboxymethylcellulose composition comprising between 2.3 wt. % and 2.9 wt. % carboxymethylcellulose; and (ii) sterilizing the composition of step (i) by autoclaving for about 3 minutes to about 12 minutes to prepare said tissue implant.   
     
     
         2 . The method of  claim 1 , wherein the carboxymethylcellulose composition is in 25 mM to 100 mM phosphate buffer. 
     
     
         3 . The method of  claim 2 , wherein the phosphate buffer has a pH from 7.2 to 8.0. 
     
     
         4 . The method of  claim 3 , wherein the water content of the tissue implant is between 57.9% and 70.3%. 
     
     
         5 . The method of  claim 1 , wherein the tissue implant is a midfacial tissue implant. 
     
     
         6 . A method of preparing a tissue implant comprising:
 (i) preparing an aqueous carboxymethylcellulose composition comprising between 2.3 wt. % and 2.9 wt. % carboxymethylcellulose; (ii) adding calcium hydroxyapatite between 5 wt. % and 65 wt. % to form a composition; and (iii) sterilizing the composition of step (ii) by autoclaving for about 3 minutes to about 12 minutes to prepare said tissue implant.   
     
     
         7 . The method of  claim 6 , wherein the carboxymethylcellulose composition is in 25 mM to 100 mM phosphate buffer. 
     
     
         8 . The method of  claim 7 , wherein the phosphate buffer has a pH from 7.2 to 8.0. 
     
     
         9 . The method of  claim 8 , wherein the water content of the tissue implant is between 57.9% and 70.3%. 
     
     
         10 . The method of  claim 6 , wherein the tissue implant is a midfacial tissue implant. 
     
     
         11 . The method of  claim 6 , wherein the calcium hydroxyapatite is added between 10 wt. % and 50 wt. %. 
     
     
         12 . The method of  claim 6 , wherein the calcium hydroxyapatite is added between 30 wt. % and 45 wt. %.