Cyclosporin derivatives for treating inflammatory diseases and conditions

Abstract

The present invention provides a method for the treatment of inflammatory diseases and/or conditions, e.g. allergic conjunctivitis, uveitis or phacoanaphylactic endophthalmitis in an eye of a mammal, said method comprising administering to said mammal in need of treatment a therapeutically effective amount of a novel cyclosporin A derivative selected from the group consisting of compounds represented by the formula: wherein R 1 is S-Alk-R wherein Alk is an alkylene linkage, preferably a methylene or poly methylene linkage, or a polyalkenylene linkage, e.g. a C 3 to C 6 alkenylenyl linkage and R is a hydrogen or a unsubstituted or substituted hydrocarbyl group.

What is claimed is: 
     
         1 . A method for the treatment of an inflammatory condition of a mammal, comprising the step of administering to a patient in need thereof, a therapeutically effective amount of a cyclosporin A derivative represented by the following formula: 
       
         
           
           
               
               
           
         
       
       wherein R 1  is S-Alk-R wherein Alk is an alkylene linkage and R is a hydrogen or a unsubstituted or substituted hydrocarbyl group.