Active compound combinations

Abstract

The invention relates to active compound combinations, in particular within a composition, which comprises (A) an amidine compound of formula (I) and a further fungicidally (B-1), insecticidally (B-2) active or plant growth regulating compound (B-3). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or reducing the mycotoxin contamination of plant or plant parts, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.

1 . A composition comprising
 (A) at least one compound according to formula (I)   
       
         
           
           
               
               
           
         
         wherein 
         R 1  is selected from the group consisting of hydrogen-a mercapto- (—SH) and a methyl group; 
         R 2  is selected from the group consisting of a methyl- and an ethyl group; 
         R 3  is selected from the group consisting of a methyl-, an ethyl- and an isopropyl group; 
         or alternatively R 2  and R 3  can form, together with the N-atom to which they are attached, a piperidyl-, a pyrrolidyl- or a 2,6-dimethylmorpholinyl-ring; 
         R 4  is selected from the group consisting of a chlorine- or a fluorine atom, a trifluoromethyl-, a difluoromethyl- and a methyl group; 
         R 5  and R 6  independently from each other, are selected from the group consisting of a hydrogen atom, a methyl- and an ethyl group; or can form, together with the C-atom to which they are attached, a cyclopropyl ring; 
         R 7  is selected from the group consisting of a chlorine atom, a tert-butyl-, a methoxy-, an ethoxy-, a trimethylsilyl- and a triethylsilyl-group, 
         n is 1 
         or salts or stereoisomers thereof, 
         and 
         (B-I) at least one further active compound selected from the group consisting of
 (B-I.2) inhibitors of the respiratory chain at complex I or II, 
 (B-I.3) inhibitors of the respiratory chain at complex III, 
 (B-I.4) Inhibitors of the mitosis and cell division, 
 (B-I.5) Compounds capable to have a multisite action, 
 (B-I.6) Compounds capable to induce a host defence, 
 (B-I.7) Inhibitors of the amino acid and/or protein biosynthesis, 
 (B-I.8) Inhibitors of the ATP production, 
 (B-I.9) Inhibitors of the cell wall synthesis, 
 (B-I.10) Inhibitors of the lipid and membrane synthesis, 
 (B-I.11) Inhibitors of the melanine biosynthesis, 
 (B-I.12) Inhibitors of the nucleic acid synthesis, 
 (B-I.13) Inhibitors of the signal transduction, 
 (B-I.14) Compounds capable to act as an uncoupler, and 
 (B-I.15) Further compounds 
 
         or 
         (B-II) at least one further insecticidally active compound, selected from the group consisting of
 (B-II.1) Acetylcholinesterase (AChE) inhibitors, 
 (B-II.2) GABA-gated chloride channel antagonists, 
 (B-II.3) Sodium channel modulators/voltage-dependent sodium channel blockers, 
 (B-II.4) Nicotinergic acetylcholine receptor agonists, 
 (B-II.5) Allosteric acetylcholine receptor modulators (agonists), 
 (B-II.6) Chloride channel activators, 
 (B-II.7) Juvenile hormone mimics, 
 (B-II.8) Miscellaneous non-specific (multi-site) inhibitors, 
 (B-II.9) Selective homopteran feeding blockers, 
 (B-II.10) Mite growth inhibitors, 
 (B-II.11) Microbial disruptors of insect midgut membranes, 
 (B-II.12) Inhibitors of mitochondrial ATP synthase, 
 (B-II.13) Uncouplers of oxidative phoshorylation via disruption of the proton gradient, 
 (B-II.14) Nicotinic acetylcholine receptor channel blockers, 
 (B-II.15) Inhibitors of chitin biosynthesis, type 0, 
 (B-II.16) Inhibitors of chitin biosynthesis, type 1, 
 (B-II.17) Moulting disruptors, 
 (B-II.18) Ecdysone receptor agonists/disruptors, 
 (B-II.19) Octopamine receptor agonists, 
 (B-II.20) Mitochondrial complex III electron transport inhibitors, 
 (B-II.21) Mitochondrial complex I electron transport inhibitors, 
 (B-II.22) Voltage-dependent sodium channel blockers, 
 (B-II.23) Inhibitors of acetyl CoA carboxylase, 
 (B-II.24) Mitochondrial complex IV electron inhibitors, 
 (B-II.25) Mitochondrial complex II electron transport inhibitors, 
 (B-II.28) Ryanodine receptor modulators, 
 
         or
 (B-III) at least one compound having plant growth regulating activity, selected from the group consisting of 
 (B-III.1) antiauxines, 
 (B-III.2) auxines, 
 (B-III.3) cytokinines, 
 (B-III.4) defoliating agents, 
 (B-III.5) ethylene inhibitors, 
 (B-III.6) ethylene generators, 
 (B-III.7) gibberellines, 
 (B-III.8) abscisinic acid, ancymidol, butralin, carbaryl, chlorphonium or its chloride, chlorpropham, dikegulac, dikegulac-sodium, flumetralin, fluoridamide, fosamine, glyphosine, isopyrimol, jasmonic acid, maleic acid hydrazide or its potassium salt, mepiquat or its chloride, piproctanyl or its bromide, prohydrojasmon, propham, 2,3,5-tri-iodobenzoic acid, 2,6-diisopropylnaphthaline, cloprop, 1-naphthylacetic acid ethylester, isoprothiolane, MCPB-ethyl [4-4-chloro-o-tolyloxy)butyric acid ethylester], N-acetylthiazolidine-4-carboxylic acid, n-decanol, pelargonic acid, N-phenylphthaliminic acid, tecnazene, triacontanol, 2,3-dihydro-5,6-diphenyl-1,4-oxathiin, 2-cyano-3-(2,4-dichlorophenyl)acrylic acid, 2-hydrazinoethanol, alorac, amidochlor, BTS 44584 [dimethyl(4-piperidinocarbonyloxy-2,5-xylyl)sulfonium-toluen-4-sulfonat], chloramben, chlorfluren, chlorfluren-methyl, dicamba-methyl, dichlorflurenol, dichlorflurenol-methyl, dimexano, etacelasil, hexafluoraceton-trihydrat, N-(2-ethyl-2H-pyrazol-3-yl)-N′-phenylurea, N-m-tolylphthalaminic acid, N-Pyrrolidinosuccinaminic acid, 3-tert-Butylphenoxyacetic acid propylester, pydanon, sodium (Z)-3-chloracrylate, 
 (B-III.9) morphactines, 
 (B-III.10) plant growth retarders/modifiers, 
 (B-III.11) plant growth stimulators, 
 (B-III.12) benzofluor, buminafos, carvone, ciobutide, clofencet, clofence-potassium, cloxyfonac, cloxyfonac-sodium, cyclanilide, cycloheximide, epocholeone, ethylchlozate, ethylene, fenridazon, heptopargil, holosulf, inabenfide, karetazan, lead arsenate, methasulfocarb, prohexadione, prohexadione-Calcium, pydanon, sintofen, triapenthenol, trinexapac and trinexapac-ethyl. 
 
       
     
     
         2 . The composition according to  claim 1 , wherein the at least one compound of formula (I) is the compound of formula (Ia) 
       
         
           
           
               
               
           
         
       
     
     
         3 . The composition according to  claim 1  wherein the at least one further active compound (B-I) is selected from the group consisting of Cyproconazole, Epoxiconazole, Flusilazole, Fluquinconazole Ipconazole, Propiconazole, Metconazole, Tebuconazole, Triadimenol, Azoxystrobin, Fluoxastrobin, Kresoxim-methyl, Picoxystrobin, Pyraclostrobin, Boscalid, Chlorothalonil, Cyprodinil, Fludioxonil, Fluopyram, Thiophanat-methyl, Penflufen, Isopyrazam, Sedaxane, Myclobutonil, Prochloraz, Spiroxamine, N-(3′,4′-dichloro-5-fluoro[1,1′-biphenyl]-2-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, Ametoctradin, 5-Chlor-6-(2,4,6-trifluorphenyl)-7-(4-methylpiperidin-1-yl)[1,2,4]triazolo[1,5-a]pyrimidin, 1-methyl-N-{2-[1′-methyl-1,1′-bi(cyclopropyl)-2-yl]phenyl}-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide, N-{2-[1,1′-bi(cyclopropyl)-2-yl]phenyl}-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide, 1-methyl-N-{2-[1′-methyl-1,1′-bi(cyclopropyl)-2-yl]phenyl}-3-(difluoromethyl)-1H-pyrazole-4-carboxamide, and N-{2-[1,1′-bi(cyclopropyl)-2-yl]phenyl}-1-methyl-3-(difluoromethyl)-1H-pyrazole-4-carboxamide. 
     
     
         4 . The composition according to  claim 1  wherein the at least one further insecticidally active compound (B-II) is selected from the group consisting of Acephate, Acequinocyl, Acrinathrin, Aldicarb, Amitraz, Anthraquinone, Azinphos-Methyl, Azocyclotin, Bendiocarb, Benfuracarb, Bifenthrin, Buprofezin, Carbaryl, Carbofuran, Carbosulfan, Cartap, Chlorfluazuron, Chlorpyrifos, Chlorpyrifos-M, Clofentezine, Clothianidin, Cyfluthrin, Cyhexatin, Cypermethrin, Cyromazine, Deltamethrin, Diazinon, Dichloropropene, Dichlorvos, Dimethoate, Disulfoton, Ethion, Ethiprole, Ethoprophos, Etofenprox, Fenamiphos, Fenitrothion, Fenobucarb, Fenpyroximate, Fenthion, Fipronil, Flubendiamide, Formetanate, Heptenophos, Hexythiazox, Imidacloprid, Metaldehyde, Methamidophos, Methiocarb, Methomyl, Methoxyfenozide, Milbemectin, M-Isothiocyanate, Permethrin, Phenthoate, Phosalone, Phoxim, Polyeder-Nuclear-Vir, Profenofos, Propargite, Prothiofos, Pyrethroids, Pyriproxifen, Quinalphos, Quinomethionate, Resmethrin, Silafluofen, Sodium-Tetrathiocarbonate, Spinosad, Spirodiclofen, Spiromesifen, Spirotetramat, Tebupirimphos, Tefluthrin, Thiacloprid, Thiamethoxam, Thiodicarb, Triazophos, Trichlorfon, and Triflumuron. 
     
     
         5 . The composition according to  claim 1  wherein the at least one compound having plant growth regulating activity (B-III) is selected from the group consisting of chlormequat, chlormequat-chloride, cyclanilide, dimethipin, ethephon, flumetralin, flurprimidol, inabenfide, mepiquat, mepiquat chloride, 1-methylcyclopropen, paclobutrazol, prohexadione-calcium, prohydrojasmon, tribufos, thidiazuron, trinexapac, trinexapac-ethyl and uniconazol. 
     
     
         6 . The composition according to  claim 1  wherein the weight ratio of (A) to (B-I), (B-II), or (B-III) is from 1:100 to 100:1. 
     
     
         7 . (canceled) 
     
     
         8 . (canceled) 
     
     
         9 . The composition according to  claim 1  further comprising adjuvants, solvents, carrier, surfactants or extenders. 
     
     
         10 . A method for curatively or preventively controlling phytopathogenic fungi of plants or reducing mycotoxin contamination of plants or plant parts comprising applying the composition according to  claim 1  to a seed, to a plant, to a fruit of the plant, to soil in which the plant is growing or to soil from which the plant is grown. 
     
     
         11 . The method according to  claim 10  comprising applying (A) and (B-I), (B-II) or (B-III) simultaneously or sequentially. 
     
     
         12 . (canceled) 
     
     
         13 . (canceled) 
     
     
         14 . (canceled) 
     
     
         15 . (canceled) 
     
     
         16 . The method according to  claim 10  wherein the composition is applied as a foliar treatment to the plant. 
     
     
         17 . The method according to  claim 16  wherein the composition is applied at a rate of from 0.1 to 10 kg/ha. 
     
     
         18 . The method according to  claim 10  wherein the composition is applied to the soil in which the plants are growing or to the soil from which the plants are grown. 
     
     
         19 . The method according to  claim 18  wherein the composition is applied at a rate of from 0.1 to 10 kg/ha. 
     
     
         20 . The method according to  claim 10  wherein the composition is applied to the seed. 
     
     
         21 . The method according to  claim 20  wherein the seed is seed of a transgenic plant. 
     
     
         22 . The method according to  claim 20  wherein the composition is applied to the seed at a rate of from 2 to 200 g/100 kg of seed. 
     
     
         23 . The composition according to  claim 1  further comprising seed.