High Viscosity Liquid Controlled Delivery System and Medical or Surgical Device

Abstract

The present invention relates to novel nonpolymeric compounds and compositions that form liquid high viscosity materials suitable for the delivery of biologically active substances in a controlled fashion, and for use as medical or surgical devices. The materials can optionally be diluted with a solvent to form a material of lower viscosity, rendering the material easy to administer. This solvent may be water insoluble or water soluble, where the water soluble solvent rapidly diffuses or migrates away from the material in vivo, leaving a higher viscosity liquid material.

1 .- 45 . (canceled) 
     
     
         46 . A composition comprising:
 sucrose acetate isobutyrate (SAIB);   benzyl alcohol; and   an anesthetic.   
     
     
         47 . The composition of  claim 46 , wherein the SAIB is present in an amount ranging from about 45 wt % to about 99.5 wt %, relative to the total weight of the composition. 
     
     
         48 . The composition of  claim 46 , wherein the benzyl alcohol is present in an amount ranging from about 10 wt % to about 30 wt %, relative to the total weight of the composition. 
     
     
         49 . The composition of  claim 46 , wherein the anesthetic is present in an amount ranging from about 5 wt % to about 20 wt %, relative to the total weight of the composition. 
     
     
         50 . The composition of  claim 46 , wherein:
 the SAIB is present in an amount ranging from about 45 wt % to about 99.5 wt %, relative to the total weight of the composition;   the solvent is present in an amount ranging from about 10 wt % to about 30 wt %, relative to the total weight of the composition; and   the anesthetic is present in an amount ranging from about 5 wt % to about 20 wt %, relative to the total weight of the composition.   
     
     
         51 . A method comprising administering the composition of  claim 46  to an animal in need thereof. 
     
     
         52 . A method comprising administering the composition of  claim 50  to an animal in need thereof. 
     
     
         53 . The method of  claim 52 , wherein the administering comprises administering parenterally. 
     
     
         54 . The method of  claim 52 , wherein the administering comprises administering topically. 
     
     
         55 . A composition comprising:
 sucrose acetate isobutyrate (SAIB);   a solvent in which the SAIB is soluble; and   bupivacaine.   
     
     
         56 . The composition of  claim 55 , wherein the SAIB is present in an amount ranging from about 45 wt % to about 99.5 wt %, relative to the total weight of the composition. 
     
     
         57 . The composition of  claim 55 , wherein the solvent is present in an amount from about 10 wt % to about 30 wt %, relative to the total weight of the composition. 
     
     
         58 . The composition of  claim 55 , wherein the bupivacaine is present in an amount ranging from about 5 wt % to about 20 wt %, relative to the total weight of the composition. 
     
     
         59 . The composition of  claim 55 , wherein:
 the SAIB is present in an amount ranging from about 45 wt % to about 99.5 wt %, relative to the total weight of the composition;   the solvent is present in an amount ranging from about 10 wt % to about 30 wt %, relative to the total weight of the composition; and   the bupivacaine is present in an amount ranging from about 5 wt % to about 20 wt %, relative to the total weight of the composition.   
     
     
         60 . A method comprising administering the composition of  claim 55  to an animal in need thereof. 
     
     
         61 . A method comprising administering the composition of  claim 59  to an animal in need thereof. 
     
     
         62 . The method of  claim 61 , wherein said administering comprises administering parenterally. 
     
     
         63 . The method of  claim 61 , wherein the administering comprises administering topically.