Local topical administration formulations containing indoxacarb

Abstract

The present invention provides formulations and methods useful in the control of ectoparasites on a domestic animal, using a formulation comprising Indoxacarb and a veterinarily acceptable carrier that is applied topically to 10% or less of the total surface area of a domestic animal. Other embodiments include these formulations also including one or more additional pesticides such as fipronil.

1 . A local, topical, spot-on formulation for control of ectoparasites on a domestic animal comprising an ectoparasitically effective amount of Indoxacarb, a veterinarily acceptable carrier, and a pyrethroid pesticide. 
     
     
         2 . The formulation of  claim 1 , wherein said ectoparasite is an Arthropod. 
     
     
         3 . The formulation of  claim 2 , wherein said Arthropod is an Insecta. 
     
     
         4 . The formulation of  claim 3 , wherein said Insecta is a flea, fly, or louse. 
     
     
         5 . The formulation of  claim 2 , wherein said Arthropod is an Arachnida. 
     
     
         6 . The formulation of  claim 1 , wherein the concentration of Indoxacarb in said formulation is at least 200 g/L. 
     
     
         7 . The formulation of  claim 1 , wherein the concentration of Indoxacarb in said formulation is at least 150 g/L. 
     
     
         8 . The formulation of  claim 1 , wherein the concentration of Indoxacarb is at least 100 g/L. 
     
     
         9 . The formulation of  claim 1 , wherein said veterinarily acceptable carrier comprises one or more of a solvent, crystallization inhibitor, adjuvant, co-solvent, colorant, surfactant, spreading oil, antioxidant, light stabilizer or tackifier. 
     
     
         10 . The formulation of  claim 9 , wherein said solvent comprises a glycol ether. 
     
     
         11 . The formulation of  claim 10 , wherein said glycol ether comprises dipropylene glycol monomethyl ether. 
     
     
         12 . The formulation of  claim 9 , wherein said solvent comprises an alkyl acetate. 
     
     
         13 . The formulation of  claim 12 , wherein said alkyl acetate is ethyl acetoacetate. 
     
     
         14 . The formulation of  claim 9 , wherein said crystallization inhibitor is triacetin. 
     
     
         15 . The formulation of  claim 1 , wherein said domestic animal is a mammal. 
     
     
         16 . The formulation of  claim 15 , wherein said mammal is a canine or feline. 
     
     
         17 - 24 . (canceled) 
     
     
         25 . A method for the control of ectoparasites on a domestic animal comprising topically applying to a localized region having a surface area of less than or equal to 10% of the total surface area of said domestic animal the formulation of  claim 1 . 
     
     
         26 . The method of  claim 25 , wherein said localized region has a surface area less than or equal to 5% of the total surface area of said domestic animal. 
     
     
         27 . The method of  claim 25 , wherein said domestic animal is a canine or a feline and said localized region of said canine or feline is less than 10 cm 2 . 
     
     
         28 . The method of  claim 25 , wherein said formulation maintains persistent efficacy on said domestic animal to the extent that no less than 5% decrease in efficacy occurs within 1 month after application of said formulation. 
     
     
         29 . The method of  claim 25 , wherein said formulation maintains persistent efficacy on said domestic animal to the extent that no less than 5% decrease in efficacy occurs after 1 aqueous solution washing of said domestic animal. 
     
     
         30 - 39 . (canceled) 
     
     
         40 . The formulation of  claim 1 , wherein said pyrethroid pesticide is permethrin. 
     
     
         41 . The formulation of  claim 40 , said formulation comprising, by weight
 1-50% Indoxacarb;   0.05-80% permethrin; and   ethyl acetoacetate.   
     
     
         42 . The formulation of  claim 40 , said formulation comprising, by weight
 1-50% Indoxacarb;   0.05-80% permethrin; and   dipropylene glycol monomethyl ether.   
     
     
         43 . The formulation of  claim 40 , said formulation comprising, by weight
 5-25% Indoxacarb;   30-75% permethrin; and   ethyl acetoacetate.   
     
     
         44 . The formulation of  claim 40 , said formulation comprising, by weight
 5-25% Indoxacarb;   30-75% permethrin; and   dipropylene glycol monomethyl ether.