Topical Patch For Pain Relief Using Cooling Agent

Abstract

Topical patch preparations that contain an odorless physiological cooling agent, and methods for using the same are provided. The subject topical patch preparations are made up of an adhesive gel composition that is present on a support, where the adhesive gel composition includes the odorless physiological cooling agent, a water-soluble polymer gel, water and a water holding agent. In using the subject topical patch preparations, the topical patch preparations are applied to a skin surface of a subject and maintained at the site of application for a period of time sufficient for an effective amount of the an odorless physiological cooling agent to be administered to the subject. The subject invention finds use in a variety of applications.

1 . A topical patch preparation comprising:
 an adhesive gel composition comprising an odorless physiological cooling agent; and   a support.   
     
     
         2 . The topical patch preparation according to  claim 1 , wherein said odorless physiological cooling agent is an acyclic amide. 
     
     
         3 . The topical patch preparation according to  claim 2 , wherein said acyclic amide is described by the formula: 
       
         
           
           
               
               
           
         
         wherein: 
         R′, R 1 , R 2  and R 3  are each C 1 -C 5  alkyl. 
       
     
     
         4 . The topical patch preparation according to  claim 3 , wherein said acyclic amide is N,2,3-Trimethyl-2-Isopropylbutanamide. 
     
     
         5 . The topical patch preparation according to  claim 4 , wherein said N,2,3-Trimethyl-2-Isopropylbutanamide is present in said adhesive gel composition in an amount ranging from about 0.1 to 15.0% (w/w). 
     
     
         6 . The topical patch preparation of  claim 1 , wherein said adhesive gel composition comprises:
 a water-soluble polymer gel;   water; and   a water retaining agent.   
     
     
         7 . The topical patch preparation according to  claim 6 , wherein said water is present in an amount ranging from about 10 to 80% (w/w). 
     
     
         8 . The topical patch preparation according to  claim 1 , wherein said adhesive gel composition has a pH ranging from about 4.0 to 7.0. 
     
     
         9 . A topical patch preparation comprising:
 (a) an adhesive gel composition having a pH ranging from about 4.0 to 7.0 and comprising:
 (i) N,2,3-Trimethyl-2-Isopropylbutanamide in an amount ranging from about 0.1 to 15.0% (w/w); 
 (ii) a water-soluble polymer gel; 
 (iii) water in an amount ranging from about 10 to 80% (w/w); and 
 (iv) a water retaining agent; and 
   (b) a support.   
     
     
         10 . The topical patch preparation according to  claim 9 , wherein said N,2,3-Trimethyl-2-Isopropylbutanamide is present in an amount ranging from about 0.5 to 10.0% (w/w). 
     
     
         11 . The topical patch preparation according to  claim 9 , wherein said water is present in an amount ranging from about 20 to 70% (w/w). 
     
     
         12 . The topical patch preparation according to  claim 11 , wherein said water is present in an amount ranging from about 30 to 60% (w/w). 
     
     
         13 . The topical patch preparation according to  claim 9 , wherein said pH ranges from about 4.0 to 6.0. 
     
     
         14 . A topical patch preparation comprising:
 (a) an adhesive gel composition having a pH ranging from about 4.0 to 6.0 and comprising:
 (i) N,2,3-Trimethyl-2-Isopropylbutanamide in an amount ranging from about 0.5 to 10.0% (w/w); 
 (ii) a water-soluble polymer gel; 
 (iii) water in an amount ranging from about 30 to 60% (w/w); 
 (iv) a water retaining agent; 
   (b) a support.   
     
     
         15 . A method of delivering an odorless physiological cooling agent to a subject, said method comprising:
 (a) applying a topical patch preparation comprising:
 (i) an adhesive gel composition comprising said odorless physiological cooling agent; and 
   (b) a support;   to a skin surface of said subject; and   
       (b) maintaining said topical patch preparation on said skin surface for a period of time sufficient for said odorless physiological cooling agent to be delivered to said subject. 
     
     
         16 . The method according to  claim 15 , wherein said odorless physiological cooling agent is an acyclic amide. 
     
     
         17 . The method according to  claim 16 , wherein said acyclic amide is present in said adhesive gel composition in an amount ranging from about 0.1 to 15.0% (w/w). 
     
     
         18 - 21 . (canceled)