Compositions and Methods for Controlling Diseases in Animals

Abstract

Disclosed herein are compositions for the treatment of a disease in an animal including yeast extract of Saccharomyces cerevisiae, Bacillus licheniformis or Bacillus subtilis spores, and a carrier. Also included are animal feed compositions including the composition for the prevention, control and/or treatment of a disease in an animal and an animal's food/feed. The compositions are useful to prevent, control, and treat diseases such as necrotic enteritis in poultry when used in combination with an anticoccidal ionophore or coccidiosis vaccine.

1 - 11 . (canceled) 
     
     
         12 . A composition for the prevention and/or control of a disease in an animal comprising; a yeast extract from  Saccharomyces cerevisiae, Bacillus subtilis , and optionally a carrier. 
     
     
         13 . The composition according to  claim 12 , comprising from about 75 wt-% to about 99 wt-% of the yeast extract from  Saccharomyces cerevisiae ; from about 1 wt-% to about 3 wt-% of the  Bacillus subtilis ; and from about 0 wt-% to about 24 wt-% of the carrier. 
     
     
         14 . The composition according to  claim 12 , comprising about 80 wt-% of the cell wall fraction from  Saccharomyces cerevisiae ; about 2.5 wt-% of QST-713 strain of  Bacillus subtilis ; and about 17.5 wt-% of the carrier. 
     
     
         15 . The composition according to  claim 12 , wherein the carrier comprises calcium carbonate, calcium sulfate, lactose, or a combination thereof. 
     
     
         16 . An animal feed composition for the prevention and/or control of a disease in an animal comprising the composition of  claim 12  and an animal foodstuff, wherein the composition is present in an amount ranging from about 0.5 pounds to about 10 pounds per ton of the animal foodstuff. 
     
     
         17 . The animal feed composition according to  claim 16 , wherein the composition for the prevention and/or control of a disease in an animal is in an amount of about 1.25 pounds per ton of the animal foodstuff. 
     
     
         18 . The animal feed composition according to  claim 16 , wherein animal foodstuff is a poultry food stuff or a swine foodstuff. 
     
     
         19 . A method for preventing and/or controlling a disease in an animal comprising administering to the animal an effective amount of a composition of  claim 12 . 
     
     
         20 . The method according to  claim 19 , wherein the animal is poultry and the disease is necrotic enteritis. 
     
     
         21 . The method according to  claim 19 , wherein the animal is swine and the disease is swine ileitis. 
     
     
         22 - 38 . (canceled) 
     
     
         39 . A composition comprising the composition of  claim 12  further comprising an anticoccidal ionophore. 
     
     
         40 . The composition of  claim 39  wherein the anticoccidal ionophore is salinomycin. 
     
     
         41 . The composition of  claim 40  wherein the salinomycin is present at a level of about 66 ppm of the composition. 
     
     
         42 . An animal feed composition comprising the composition for the treatment of necrotic enteritis in an animal of  claim 39 , and an animal foodstuff, wherein the composition for the treatment of a disease in an animal is in an amount of about 0.5 pounds to about 10 pounds per ton of the animal foodstuff. 
     
     
         43 . A method for improving the performance of an ionophore in the treatment of necrotic enteritis in an animal comprising administering to the animal the composition of  claim 39 . 
     
     
         44 . (canceled) 
     
     
         45 . A method for preventing disease in an animal, comprising vaccinating the animal with a coccidiosis vaccine and administering to the animal the composition of  claim 12 . 
     
     
         46 . The method of  claim 45  wherein the animal is poultry and the disease is necrotic enteritis. 
     
     
         47 . The method of  claim 45  wherein the vaccine comprises a non-attenuated, live sporulated oocyst coccidiosis vaccine. 
     
     
         48 . (canceled) 
     
     
         49 . The composition of  claim 12  wherein the  Bacillus subtilis  comprises the QST-713 strain of  Bacillus subtilis.