Methods of treating ocular and other diseases with syn-134r polypeptide

Abstract

Disclosed herein TPV1 is a method of treating ocular and systemic conditions by administering IL-10 and TPV134R polypeptides.

1 . A method for the treatment of an ocular condition selected from keratoconjunctivitis sicca and diminished corneal sensitivity, the method comprising administering to a patient having the condition a composition comprising the polypeptide of SEQ ID NO:10. 
     
     
         2 .- 8 . (canceled) 
     
     
         9 . The method of  claim 1 , wherein the polypeptide comprises an amino acid sequence that is at least 95% identical to SEQ ID NO: 10. 
     
     
         10 . The method of  claim 9 , wherein the polypeptide comprises an amino acid sequence that is at least 99% identical to SEQ ID NO:10. 
     
     
         11 .- 12 . (canceled) 
     
     
         13 . The method of  claim 1 , wherein the polypeptide is substantially pure. 
     
     
         14 . The method of  claim 1 , wherein the polypeptide is administered topically to the eye. 
     
     
         15 . The method of  claim 1 , wherein the polypeptide is administered by injecting it into the eye. 
     
     
         16 .- 17 . (canceled) 
     
     
         18 . The method of  claim 1 , wherein the ocular condition is keratoconjunctivitis sicca. 
     
     
         19 . The method of  claim 1 , wherein the ocular condition is diminished corneal sensitivity.