Test agent for visceral obesity and use thereof

Abstract

Disclosed are: a method for detecting (diagnosing) visceral obesity in a subject; a test agent useful for the method; a method for searching for a substance that can be used as an active ingredient for ameliorating visceral obesity; and an ameliorating agent for visceral obesity or a medicinal agent for preventing a metabolic disease developed as a result of the progression of visceral obesity. As the test agent, a polynucleotide which comprises at least 15 nucleotides and can hybridize with a nucleotide sequence for coiled-coil domain containing protein 3 (CCDC3) gene or a nucleotide sequence complementary to the nucleotide sequence under stringent conditions or an antibody capable of recognizing CCDC3 protein is used.

1 . An anti-visceral obesity agent that comprises as an active ingredient a nucleic acid that suppresses CCDC3 gene expression or CCDC3 protein function, or a neutralizing antibody against the CCDC3 protein. 
     
     
         2 . An antidiabetic agent that comprises as an active ingredient a nucleic acid that suppresses CCDC3 gene expression or CCDC3 protein function, or a neutralizing antibody against the CCDC3 protein.