US2013313735A1PendingUtilityA1

Electrospun Calcium Phosphate Nanofibers

55
Assignee: CORNELL RES FOUNDATION INCPriority: Sep 1, 2006Filed: Jul 19, 2013Published: Nov 28, 2013
Est. expirySep 1, 2026(~0.1 yrs left)· nominal 20-yr term from priority
Inventors:Jian TanYong Lak Joo
C04B 35/624A61L 27/50C04B 2111/00836C04B 2235/5264C12N 2533/30A61L 27/3821C04B 2235/441D01D 5/003C12N 2533/40C12N 5/0654A61P 19/00B82Y 5/00C04B 2235/5284C04B 35/447A61L 27/3843C12N 2533/18Y10T428/2998D01D 5/0038C04B 2235/447C04B 35/62886C04B 35/63416C04B 30/02C04B 35/62849C04B 35/62881C04B 2235/3212C04B 2235/443C04B 35/62268B82Y 30/00A61L 27/12
55
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

Calcium-phosphate nanofiber matrices comprising randomly dispersed crystalline calcium-phosphate nanofibers are provided. The nanofibers are synthesized using sol-gel methods combined with electrospinning The nanofibers may be hollow, solid or may comprise a calcium-phosphate shell surrounding a polymer containing inner core to which biologically functional additives may be added. The nanofiber matrices may be used to culture bone and dental cells, and as implants to treat bone, dental or periodontal diseases and defects.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method to synthesize a nanofiber, comprising the steps of:
 (a) sol-gel synthesizing a calcium phosphate sol-gel precursor in an aqueous solvent; and   (b) electro-spinning the sol-gel precursor to form a nanofiber.   
     
     
         2 . The method of  claim 1 , further comprising the step of calcinating the nanofiber produced in step (b). 
     
     
         3 . A method to synthesize a nanofiber, comprising the steps of:
 (a) sol-gel synthesizing a calcium phosphate sol-gel precursor in an aqueous solvent;   (b) sol-gel synthesizing a polymeric substance sol-gel precursor in an aqueous solvent; and   (c) co-axially electro-spinning the calcium phosphate sol-gel precursor with the polymeric substance sol-gel precursor to form a nanofiber, wherein the nanofiber comprises a calcium phosphate shell around a core comprising the polymeric substance.   
     
     
         4 . The method of  claim 3 , further comprising the step of calcinating the nanofiber produced in step (c). 
     
     
         5 . The method of  claim 1 , wherein the calcium phosphate sol-gel precursor further comprises a polymer binder. 
     
     
         6 . The method of  claim 1 , wherein the sol-gel synthesis of the calcium phosphate sol-gel precursor in step (a) comprises the steps of:
 (i) hydrolyzing a phosphate-based material in an aqueous solvent;   (ii) adding a calcium-based material to the hydrolyzed phosphate-based material to form a calcium-phosphate sol-gel precursor solution;   (iii) optionally aging the calcium-phosphate sol-gel precursor solution for at least 16 hours; and   (iv) optionally adding a polymer binder to the calcium-phosphate solution.   
     
     
         7 . The method of  claim 6 , wherein the calcium phosphate sol-gel precursor synthesized by said method is a polymer comprising a plurality of linearly-arranged oligomeric derivatives containing a Ca—O—P bond. 
     
     
         8 . The method of  claim 6 , wherein the molecular weight of the calcium phosphate sol-gel precursor is between 10,000 amu and 300,000 amu. 
     
     
         9 . The method of  claim 8 , wherein the molecular weight of the calcium phosphate sol-gel precursor is between 100,000 amu and 200,000 amu. 
     
     
         10 . The method of  claim 6 , wherein the Calcium:Phosphate:water:solvent molar ratio is about 1.67:1:3-6.5:7.4-14.8. 
     
     
         11 . The method of  claim 10 , wherein the Calcium:Phosphate:water:solvent molar ratio is about 1.67:1:6.5:14.8. 
     
     
         12 . The method of  claim 6 , wherein the calcium-based material is selected from the group consisting of calcium nitrate, calcium acetate, calcium ethoxide and calcium glycolate. 
     
     
         13 . The method of  claim 6 , wherein the phosphate-based material is selected from the group consisting of triethyl phosphate and phosphate ethers. 
     
     
         14 . The method of  claim 6 , wherein the aqueous solvent comprise an alcohol. 
     
     
         15 . The method of  claim 14 , wherein the alcohol is ethanol. 
     
     
         16 . The method of  claim 6 , wherein the polymer binder is selected from the group consisting of polyvinyl alcohols, polyglycolic acids and copolymers thereof 
     
     
         17 . The method of  claim 16 , wherein the polymer binder is added in the form of a 10% by weight aqueous solution. 
     
     
         18 . The method of  claim 17 , wherein the 10% by weight polymer binder aqueous solution is mixed with the calcium phosphate sol-gel precursor at a volumetric ratio between about 1.5 to about 4.5. 
     
     
         19 . The method of  claim 3 , wherein the core-forming polymeric substance comprises a biodegradable polymer. 
     
     
         20 . The method of  claim 19 , wherein the biodegradable polymer is an immiscible polymer that does not react or dissolve in ethanol. 
     
     
         21 . The method of  claim 20 , wherein the polymer is selected from the group consisting of pyridine, poly(glycolic acid), poly(lactic) acid and poly(lactic acid-co-glycolic acid). 
     
     
         22 . The method of  claim 20 , wherein the polymer is selected from the group consisting of silica-based compounds. 
     
     
         23 . The method of  claim 22 , wherein the silica-based compound is tetraethyl orthosilicate (TEOS). 
     
     
         24 . The method of  claim 3 , wherein the sol-gel synthesis of the polymeric substance precursor in step (b) comprises the steps of:
 (ii) catalytically hydrolyzing the polymer in an aqueous solvent; and   (ii) heating the reaction product of step (i), wherein the sol-gel synthesized polymeric substance precursor comprises at least one linear chain of oligomer derivatives.   
     
     
         25 . The method of  claim 2 , wherein the calcination step comprises heating the electrospun fiber to a temperature greater than about 350° C. 
     
     
         26 . The method of  claim 25 , wherein the calcination step comprises heating the electrospun fibers to a temperature of between about 500° C. and about 1,200° C. 
     
     
         27 . The method of  claim 26 , wherein the calcination step comprises heating the electrospun fiber to a temperature of between about 600° C. and about 800° C. 
     
     
         28 . The method of  claim 2 , wherein the calcination step comprises heating the electrospun fiber for between two and twelve hours. 
     
     
         29 . The method of  claim 28 , wherein the calcination step comprises heating the electrospun fiber for between about five to seven hours. 
     
     
         30 . The method of  claim 1 , further comprising the step of evaporating the aqueous solvent.

Join the waitlist — get patent alerts

Track US2013313735A1 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.