Isoxazole derivatives for use as fungicides

Abstract

The present invention relates to isoxazole compounds of formula (I) having fungicidal activity, to agricultural compositions comprising them, and to the use of said compounds and compositions in agriculture for the control of microbial pests, particularly fungal pests, on plants

1 . A compound of the formula (I) 
       
         
           
           
               
               
           
         
         wherein R 1  is H or acyl; 
         or an agrochemically acceptable salt thereof. 
       
     
     
         2 . A compound according to  claim 1  wherein R 1  is H. 
     
     
         3 . A compound according to  claim 1  which is the (S)-enantiomer of the compound of formula (I). 
     
     
         4 . A compound according to  claim 3  which is (S)-[3-(4-chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)isoxazol-4-yl]pyridin-3-yl-methanol 
       
         
           
           
               
               
           
         
       
     
     
         5 . A compound according to  claim 3  having an enantiomeric excess of (S) to (R) of at least 80%. 
     
     
         6 . A composition comprising a compound according to  claim 1 , or an agrochemically acceptable salt thereof, and an agrochemically acceptable diluent or carrier. 
     
     
         7 . A composition according to  claim 6  further comprising at least one additional fungicide or systemically acquired resistance inducer. 
     
     
         8 . A method of controlling or preventing infestation of cultivated plants, plant propagation material, or a technical material, by pathogenic microorganisms, comprising applying a compound according to  claim 1 , to said plants, parts thereof or the locus thereof, plant propagation material, or technical material in an amount effective to control said microorganisms. 
     
     
         9 . A method according to  claim 9 , wherein said plant propagation material comprises seeds. 
     
     
         10 . A method according to  claim 10  wherein the pathogenic microorganism is a fungal organism. 
     
     
         11 . A method according to  claim 11  wherein the fungal organism is selected from  Septoria tritici, Stagonospora nodorum, Phytophthora infestans, Botrytis cinerea, Sclerotinia homoeocarpa  and  Puccinia recondite.    
     
     
         12 . A method of treating a fungal infection in a subject in need thereof comprising administering a compound according to  claim 1  or a pharmaceutically acceptable salt thereof to said subject in an amount effective to treat said fungal infection.