Therapeutic agent for pulmonary small cell carcinoma

Abstract

The invention aims to clarify further functions of a T-cell leukemia translocation-associated gene (TCTA) protein-derived peptide and provide a novel application of the peptide. The invention provides a therapeutic agent for pulmonary small cell carcinoma or a cell growth inhibitor of pulmonary small cell carcinoma, comprising any peptide described in SEQ ID NOs 1 to 5.

1 . A method for treating pulmonary small cell carcinoma, comprising administering a peptide selected from the group consisting of the following (I) to (VI): 
       
         
           
                 
               
                   (I) 
                 
                   Gly Gln Asn, 
                 
                     
                 
                   (II) 
                 
                   (SEQ ID No. 1) 
                 
                   Gly Gln Asn Gly Ser Thr, 
                 
                     
                 
                   (III) 
                 
                   (SEQ ID No. 2) 
                 
                   Gly Gln Asn Gly Ser Thr Pro Asp Gly Ser Thr His 
                 
                     
                 
                   Phe Pro Ser Trp Glu Met Ala Ala Asn Glu Pro Leu 
                 
                     
                 
                   Lys Thr His Arg Glu, 
                 
                     
                 
                   (IV) 
                 
                   (SEQ ID No. 3) 
                 
                   Gly Gln Asn Gly Ser Thr Pro Asp Gly Ser Thr His 
                 
                     
                 
                   Phe Pro Ser Trp Glu Met Ala Ala Asn, 
                 
                     
                 
                   (V) 
                 
                   (SEQ ID No. 4) 
                 
                   Gly Gln Asn Gly Ser Thr Pro Asp Gly Ser Thr His 
                 
                     
                 
                   Phe, 
                 
                   and 
                 
                     
                 
                   (VI) 
                 
                   (SEQ ID No. 5) 
                 
                   Pro Gly Leu Gly Gly Gln Asn Gly Ser Thr Pro Asp 
                 
                     
                 
                   Gly Ser Thr His Phe 
                 
                   to a subject in need thereof. 
                 
             
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
               
            
           
         
       
     
     
         2 . The method of  claim 1 , wherein the peptide is represented by SEQ ID No. 2. 
     
     
         3 . The method of  claim 1 , wherein the peptide is derived from T-cell leukemia translocation-associated gene (TCTA) protein. 
     
     
         4 . The method of  claim 1 , wherein the pulmonary small cell carcinoma is metastatic pulmonary small cell carcinoma. 
     
     
         5 . (canceled) 
     
     
         6 . A method for inhibiting cell growth of pulmonary small cell carcinoma, comprising administering a peptide selected from the group consisting of the following (I) to (VI): 
       
         
           
                 
               
                   (I) 
                 
                   Gly Gln Asn, 
                 
                     
                 
                   (II) 
                 
                   (SEQ ID No. 1) 
                 
                   Gly Gln Asn Gly Ser Thr, 
                 
                     
                 
                   (III) 
                 
                   (SEQ ID No. 2) 
                 
                   Gly Gln Asn Gly Ser Thr Pro Asp Gly Ser Thr His 
                 
                     
                 
                   Phe Pro Ser Trp Glu Met Ala Ala Asn Glu Pro Leu 
                 
                     
                 
                   Lys Thr His Arg Glu, 
                 
                     
                 
                   (IV) 
                 
                   (SEQ ID No. 3) 
                 
                   Gly Gln Asn Gly Ser Thr Pro Asp Gly Ser Thr His 
                 
                     
                 
                   Phe Pro Ser Trp Glu Met Ala Ala Asn, 
                 
                     
                 
                   (V) 
                 
                   (SEQ ID No. 4) 
                 
                   Gly Gln Asn Gly Ser Thr Pro Asp Gly Ser Thr His 
                 
                     
                 
                   Phe, 
                 
                   and 
                 
                     
                 
                   (VI) 
                 
                   (SEQ ID No. 5) 
                 
                   Pro Gly Leu Gly Gly Gln Asn Gly Ser Thr Pro Asp 
                 
                     
                 
                   Gly Ser Thr His Phe 
                 
                   to a subject in need thereof. 
                 
             
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
               
            
           
         
       
     
     
         7 . The method of  claim 6 , wherein the peptide is represented by SEQ ID No. 2. 
     
     
         8 . The method of  claim 6 , wherein the peptide is derived from T-cell leukemia translocation-associated gene (TCTA) protein. 
     
     
         9 . (canceled)