US2013288361A1PendingUtilityA1

Neurodegenerative diseases and methods of modeling

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Assignee: HARVARD COLLEGEPriority: Apr 15, 2008Filed: Jan 25, 2013Published: Oct 31, 2013
Est. expiryApr 15, 2028(~1.7 yrs left)· nominal 20-yr term from priority
Inventors:Kevin C. EgganFrancesco Paolo Di Giorgio
A61K 39/395A61K 38/22A61K 38/43G01N 2333/90283A61K 35/76G01N 33/5058A61K 31/7088G01N 2800/28C12N 5/10
63
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Claims

Abstract

Disclosed are embryonic stem cells and motor neurons derived from mice carrying transgenic alleles of the normal or mutant human SOD1 gene. Also disclosed are in vitro systems employing such SOD1 transgenic motor neurons for the study of neural degenerative disease.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . An embryonic stem cell comprising a SOD1 mutant allele. 
     
     
         2 .- 80 . (canceled)

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