Closed Loop Blood Glucose Control Algorithm Analysis

Abstract

Methods and devices to generate a tool for testing, simulating and/or modifying a closed loop control algorithm are provided. Embodiments include receiving glucose data for a predetermined time period, determining a variation in the glucose level based on the received glucose data, filtering a received glucose data based on the determined variation, substituting a negative change in the glucose data value with a predetermined value to generate a sequence of modified glucose values, and integrating the sequence of modified glucose values to determine an uncontrolled blood glucose excursion condition.

What is claimed is: 
     
         1 . A method, comprising:
 receiving glucose data for a predetermined time period;   determining a variation in the glucose level based on the received glucose data;   filtering the received glucose data based on the determined variation;   substituting a negative change in the glucose data value with a predetermined value to generate a sequence of modified glucose values; and   integrating the sequence of modified glucose values to determine an uncontrolled blood glucose excursion condition.   
     
     
         2 . The method of  claim 1  wherein the predetermined value includes an average value. 
     
     
         3 . The method of  claim 2  wherein the average value includes an average of ten prior values. 
     
     
         4 . The method of  claim 2  wherein the average value includes a weighted average value. 
     
     
         5 . The method of  claim 4  wherein the weighed average value includes an equally weighted average value. 
     
     
         6 . The method of  claim 4  wherein the weighed average value includes an unequally weighted average value. 
     
     
         7 . The method of  claim 2  wherein the average value includes an unweighted average value. 
     
     
         8 . The method of  claim 1  wherein filtering based on the predetermined variation includes filtering out glucose values associated with a negative change. 
     
     
         9 . The method of  claim 8  wherein the negative change is determined based on an immediate prior glucose value. 
     
     
         10 . An apparatus, comprising:
 a user interface;   one or more processors operatively coupled to the data user interface; and   a memory for storing instructions which, when executed by the one or more processors, causes the one or more processors to receive glucose data for a predetermined time period, determine a variation in the glucose level based on the received glucose data, filter the received glucose data based on the determined variation, substitute a negative change in the glucose data value with a predetermined value to generate a sequence of modified glucose values, and integrating the sequence of modified glucose values to determine an uncontrolled blood glucose excursion condition.   
     
     
         11 . The apparatus of  claim 10  wherein the predetermined value includes an average value. 
     
     
         12 . The apparatus of  claim 11  wherein the average value includes an average of ten prior values. 
     
     
         13 . The apparatus of  claim 10  wherein the average value includes a weighted average value. 
     
     
         14 . The apparatus of  claim 13  wherein the weighed average value includes an equally weighted average value. 
     
     
         15 . The apparatus of  claim 13  wherein the weighed average value includes an unequally weighted average value. 
     
     
         16 . The apparatus of  claim 10  wherein the average value includes an unweighted average value. 
     
     
         17 . The apparatus of  claim 10  wherein the memory for storing instructions which, when executed by the one or more processors, causes the one or more processors to filter out glucose values associated with a negative change. 
     
     
         18 . The apparatus of  claim 17  wherein the negative change is determined based on an immediate prior glucose value. 
     
     
         19 . One or more storage devices having processor readable code embodied thereon, said processor readable code for programming one or more processors to perform a control test algorithm, comprising:
 receiving glucose data for a predetermined time period;   determining a variation in the glucose level based on the received glucose data;   filtering the received glucose data based on the determined variation;   substituting a negative change in the glucose data value with a predetermined value to generate a sequence of modified glucose values; and   integrating the sequence of modified glucose values to determine an uncontrolled blood glucose excursion condition.