US2013274472A1PendingUtilityA1

Sodium salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide

Assignee: TAKAKURA KEIKOPriority: Sep 30, 2010Filed: Sep 29, 2011Published: Oct 17, 2013

Est. expirySep 30, 2030(~4.2 yrs left)· nominal 20-yr term from priority

Inventors:Keiko Takakura Namika Nakamatsu Sakiko Takeshima Sayuri Uehara

A61P 31/16A61P 31/00A61P 31/12A61K 9/19C07D 241/24C07B 2200/13

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Claims

Abstract

A preparation replete with crystals of a sodium salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection.

Claims

exact text as granted — not AI-modified

1 . A crystal of a sodium salt of 6-fluoro-3-hydroxy-2-pyrazinecarboxamide or a hydrate thereof. 
     
     
         2 . An injectable preparation containing a crystal of a sodium salt of 6-fluoro-3-hydroxy-2-pyrazinecarboxamide or a hydrate thereof. 
     
     
         3 . A lyophilized preparation containing a crystal of a sodium salt of 6-fluoro-3-hydroxy-2-pyrazinecarboxamide. 
     
     
         4 . A process for producing a lyophilized preparation containing a crystal of a sodium salt of 6-fluoro-3-hydroxy-2-pyrazinecarboxamide, comprising the steps:
 (1) cooling an aqueous solution containing a sodium salt of 6-fluoro-3-hydroxy-2-pyrazinecarboxamide to produce a frozen product;   (2) increasing the temperature of the frozen product;   (3) cooling the frozen product again; and   (4) carrying out lyophilization.   
     
     
         5 . The process according to  claim 4 , wherein the achieving temperature of the frozen product falls within the range of −15 to −5° C. in the step of increasing the temperature of the frozen product.

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