Nf-kb inhibitor

Abstract

An NF-κB inhibitor which can be easily obtained and consumed in daily dietary life and can inhibit transcription activation by NF-κB is provided. When osteoblasts in which NF-κB is activated by TNF-α is cultured in a medium containing Sargassum horneri or a processed product thereof, for example, a Sargassum horneri water extract of molecular weight up to 3,000, transcription activation by NF-κB can be inhibited. In addition, when osteoclast precursor cells in which NF-κB is activated by RANKL is cultured in a medium containing Sargassum horneri or a processed product, for example, a Sargassum horneri water extract thereof of molecular weight up to 3,000, transcription activation by NF-κB can be inhibited.

1 . An NF-κB inhibitor comprising  Sargassum horneri  or a processed product thereof as an active ingredient. 
     
     
         2 . The NF-κB inhibitor according to  claim 1 , wherein the processed product of  Sargassum horneri  is an extract of  Sargassum horneri.    
     
     
         3 . The NF-κB inhibitor according to  claim 2 , wherein the extract of  Sargassum horneri  is a water extract of  Sargassum horneri.    
     
     
         4 . The NF-κB inhibitor according to  claim 3 , wherein the water extract of  Sargassum horneri  is a  Sargassum horneri  water extract having a molecular weight of 3,000 or less. 
     
     
         5 . A composition for inhibiting transcription activation by NF-κB, comprising the NF-κB inhibitor according to  claim 1 . 
     
     
         6 . A composition for inhibiting transcription activation by NF-κB, comprising the NF-κB inhibitor according to  claim 2 . 
     
     
         7 . A composition for inhibiting transcription activation by NF-κB, comprising the NF-κB inhibitor according to  claim 3 . 
     
     
         8 . A composition for inhibiting transcription activation by NF-κB, comprising the NF-κB inhibitor according to  claim 4 .