Method of Use of Substrate Having Properties of Keratinous Tissue

Abstract

Method of evaluating a product by applying a substance to the surface of an artificial substrate to form a substance-coated surface and performing an analysis of the substance-coated surface. The surface of the substrate may have one or more of the following properties: a total surface energy of from about 15 mJ/m 2 to about 50 mJ/m 2 , a polar component of the total surface energy of from about 0 mJ/m 2 to about 15 mJ/m 2 , and a zeta-potential at a pH of about 5.0 of from about −30 mV to about 30 mV.

What is claimed is: 
     
         1 . A method of product evaluation comprising the steps of:
 a) providing an artificial first substrate having a physical property representative of mammalian keratinous tissue;   b) providing a second substrate;   c) contacting at least one of the substrates to an instrument capable of measuring frictional force;   d) bringing the first substrate into contact with the second substrate;   e) moving the first substrate with respect to the second substrate in a controlled manner while maintaining substantially continuous contact between the first substrate and the second substrate; and   f) measuring the frictional force generated by the movement of the first substrate relative to the second substrate.   
     
     
         2 . The method of  claim 1 , wherein a substance is applied to at least one of the substrates. 
     
     
         3 . The method of  claim 1 , wherein at least one of the substrates is rinsed at least once. 
     
     
         4 . The method of  claim 1 , wherein the movement of the first substrate with respect to the second substrate is repeated at least once. 
     
     
         5 . The method of  claim 1 , wherein the artificial first substrate is comprised of polyurethane, polydimethylsiloxane, linear polyethylene, isotactic polypropylene, polystyrene, polyamide, and combinations thereof. 
     
     
         6 . The method of  claim 1 , wherein the artificial first substrate is textured. 
     
     
         7 . The method of  claim 6 , wherein the texture of the artificial first substrate mimics mammalian keratinous tissue. 
     
     
         8 . The method of  claim 1 , wherein the physical property representative of mammalian keratinous tissue is selected from the group consisting of a total surface energy of from about 15 mJ/m 2  to about 50 mJ/m 2 , a polar component of the total surface energy of from about 0 mJ/m 2  to about 15 mJ/m 2 , a zeta-potential at a pH of about 5.0 of from about −30 mV to about 30 mV, and combinations thereof. 
     
     
         9 . The method of  claim 1 , wherein the second substrate is hair. 
     
     
         10 . The method of  claim 1 , wherein said substance is a consumer product. 
     
     
         11 . The method of  claim 10 , wherein the consumer product is selected from the group consisting of a hair care product, a skin care product, a cosmetic product, and a household cleaning product. 
     
     
         12 . A method of modeling the deposition of a substance onto mammalian keratinous tissue, comprising the steps of:
 a) applying a substance to a surface of an artificial substrate to form a substance-coated surface, wherein the substrate surface demonstrates at least one physical property selected from the group consisting of a total surface energy of from about 15 mJ/m 2  to about 50 mJ/m 2 , a polar component of the total surface energy of from about 0 mJ/m 2  to about 15 mJ/m 2 , a zeta-potential at a pH of about 5.0 of from about −30 mV to about 30 mV, texture that mimics mammalian keratinous tissue, and combinations thereof; and   b) assessing the retention of substance on the surface of the substrate.   
     
     
         13 . The method of  claim 12 , wherein the portion of substance is removed by means of rinsing. 
     
     
         14 . The method of  claim 12 , wherein the portion of substance is removed by means of wiping. 
     
     
         15 . The method of  claim 12 , wherein the substance is applied by bringing an article of manufacture comprising the substance into contact with the surface of the substrate. 
     
     
         16 . A method of modeling adhesion of an adhesive article of manufacture onto keratinous tissue, comprising:
 a) placing the article of manufacture in contact with an artificial substrate to form a substrate-adhesive complex, wherein the substrate surface demonstrates at least one physical property selected from the group consisting of a total surface energy of from about 15 mJ/m 2  to about 50 mJ/m 2 , a polar component of the total surface energy of from about 0 mJ/m 2  to about 15 mJ/m 2 , a zeta-potential at a pH of about 5.0 of from about −30 mV to about 30 mV, texture that mimics mammalian keratinous tissue, and combinations thereof; and   b) performing at least one analysis of the substrate-adhesive complex.   
     
     
         17 . The method of  claim 16 , further comprising removing the adhesive article of manufacture from the artificial substrate. 
     
     
         18 . The method of  claim 17 , further comprising assessing the force required for removal of the article of manufacture from the artificial substrate. 
     
     
         19 . The method of  claim 17 , further comprising the step of performing at least one analysis of the substrate. 
     
     
         20 . The method of  claim 16 , wherein the adhesive article of manufacture is a transdermal delivery device.