Camptothean-peptide conjugates and pharmaceutical compositions containing the same

Abstract

The present invention relates to a novel compound of use in the improved delivery of therapeutic drug agents into target cells or tissues, composition comprising the same and uses thereof. The compound is more specifically a conjugate of a peptidic moiety and a camptothecin, a derivative or analog thereof which provides numerous benefits, including enhancement in terms of aqueous solubility, pharmacokinetics and tissue distribution, enlargement of the therapeutic index, and limitation of the inter-patient metabolic variability, as well as improvement of delivery of the biologically active ingredient to the target cells or tissues.

1 - 42 . (canceled) 
     
     
         43 . A pharmaceutical composition comprising a conjugate selected from the group consisting of 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         and a pharmaceutically acceptable carrier. 
       
     
     
         44 . The composition of  claim 43 , wherein the conjugate is 
       
         
           
           
               
               
           
         
       
     
     
         45 . The composition of  claim 43 , wherein the conjugate is 
       
         
           
           
               
               
           
         
       
     
     
         46 . The composition of  claim 43 , wherein the conjugate is