PCan065 Antibody Compositions and Methods of Use

Abstract

The invention provides isolated anti-PCan065 antibodies that bind to PCan065. The invention also encompasses compositions comprising an anti-PCan065 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-PCan065 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-PCan065 antibodies. The invention encompasses a method of producing the anti-PCan065 antibodies. Other aspects of the invention are a method of killing an PCan065-expressing cancer cell, comprising contacting the cancer cell with an anti-PCan065 antibody and a method of alleviating or treating an PCan065-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-PCan065 antibody to the mammal.

1 - 78 . (canceled) 
     
     
         79 . A kit for detection and quantitation of PCan065 comprising an anti-PCan065 antibody, wherein PCan065 can be quantified in the range of about 0.015-6 ng/mL with the kit. 
     
     
         80 . The kit of  claim 79  wherein the antibody is a polyclonal, monoclonal, humanized, or human antibody. 
     
     
         81 . The kit of  claim 79  wherein the antibody is detectably labeled. 
     
     
         82 . The kit of  claim 81  wherein the label is selected from the group comprising fluorescent, radio and enzymatic labels. 
     
     
         83 . The kit of  claim 79  further comprising diluents or buffers. 
     
     
         84 . The kit of  claim 79  further comprising a package insert. 
     
     
         85 . The kit of  claim 84  wherein the package insert indicates the kit is used for detecting PCan065 levels. 
     
     
         86 . The kit of  claim 84  wherein the package insert provides instructions for the intended in-vitro or diagnostic use of the kit.