US2013224276A1PendingUtilityA1

Compositions and methods for coating medical implants

63
Assignee: ANGIOTECH INT AGPriority: May 24, 2002Filed: Mar 18, 2013Published: Aug 29, 2013
Est. expiryMay 24, 2022(expired)· nominal 20-yr term from priority
Inventors:William L. HunterDavid GravettPhilip M. ToleikisRichard LigginsTroy Loss
A61P 43/00A61L 29/085A61L 2300/416A61L 29/16A61L 27/34A61L 2300/404A61L 27/54A61P 31/00
63
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Claims

Abstract

Medical implants are provided which release an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, and/or platinum complex, thereby inhibiting or reducing the incidence of infection associated with the implant.

Claims

exact text as granted — not AI-modified
1 - 12 . (canceled) 
     
     
         13 . A composition, comprising a polymer and a fluoropyrimidine, wherein said fluoropyrimidine is present in said composition at a concentration of less than 10 −4  M. 
     
     
         14 . The composition according to  claim 13  wherein said fluoropyrimidine is present in said composition at a concentration of less than any one of 10 −5  M, 10 −6  M, or 10 −7  M. 
     
     
         15 . The composition according to  claim 13  wherein said polymer is a non-biodegradable polymer. 
     
     
         16 . The composition according to  claim 13  wherein said polymer is a polyurethane. 
     
     
         17 . The composition according to  claim 13  wherein said polymer is a poly(lactide-co-glycolide). 
     
     
         18 . The composition according to  claim 13  wherein said fluoropyrimidine is 5-fluorouracil. 
     
     
         19 . A method for reducing or inhibiting infection associated with a medical implant, comprising the step of introducing into a patient a medical implant which has been covered or coated with a fluoropyrimidine. 
     
     
         20 . The method according to  claim 19  wherein said fluoropyrimidine is 5-fluorouracil. 
     
     
         21 . A method for making medical implants, comprising covering or coating a medical implant with a fluoropyrimidine. 
     
     
         22 . The method according to  claim 21  wherein said fluoropyrimidine is 5-fluorouracil. 
     
     
         23 . The method according to  claim 21  wherein said medical implant covered or coated by dipping or by impregnation.

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