Lrrk2 polynucleotides and trangenic animals

Abstract

A polynucleotide consisting of the base sequence of SEQ ID NO:2, or a complementary strand thereto, wherein the X is one of the group being defined by the bases A, C or T. A primer and a probe specific for that polynucleotide, wherein the primer and/or probe contains at least 10 consecutive nucleotides, and finally use of the probe for proving parkinsonism inheritance.

1 - 3 . (canceled) 
     
     
         4 . A transgenic non-human animal having integrated within its genome a nucleic acid comprising the nucleotide sequence of SEQ ID NO:2, wherein the nucleotide at position 6055 of SEQ ID NO:2 is A, C, or T. 
     
     
         5 . The transgenic non-human animal of  claim 4 , wherein the nucleotide at position 6055 of SEQ ID NO:2 is A. 
     
     
         6 . The transgenic non-human animal of  claim 4 , wherein the nucleotide at position 6055 of SEQ ID NO:2 is C. 
     
     
         7 . The transgenic non-human animal of  claim 4 , wherein the nucleotide at position 6055 of SEQ ID NO:2 is T. 
     
     
         8 . The transgenic non-human animal of  claim 4 , wherein the animal is a mouse.