Pathological animal model simultaneously developing testicular pain or discomfort behaviors and urinary frequency

Abstract

A pathologic animal model characterized in that a pain or discomfort behavior and urinary frequency are induced by administering a stimulative substance into the testes of a small-sized mammal, and a screening method for a therapeutic agent for pelvic pain syndrome, particularly non-bacterial chronic prostatitis, which comprises administering a test substance to the pathologic animal model and measuring pain or discomfort behaviors and/or urinary frequency.

1 .- 4 . (canceled) 
     
     
         5 . A screening method for therapeutic agents for a pelvic pain syndrome, comprising:
 administering acetic acid or nerve growth factor (NGF) into the testes of a small-sized  mammal; and   administering a test substance and measuring pain or discomfort behaviors and/or urinary frequency.   
     
     
         6 . The screening method for therapeutic agents described in  claim 5 , wherein the pelvic pain syndrome is urological pain syndrome. 
     
     
         7 . The screening method for therapeutic agents described in  claim 6 , wherein the urological pain syndrome is non-bacterial chronic prostatitis. 
     
     
         8 . The screening method described in  claim 7 , which comprises administering the test substance before or after administration of a stimulative substance into the testes of the pathologic animal model, and selecting the test substance that improves the pain or discomfort behavior and/or urinary frequency.