Ophthalmic compositions of parasympathetic stimulants and anti-inflammatories for use in the treatment of presbyopia

Abstract

Ophthalmic compositions for the treatment of presbyopia, including combinations of parasympathomimetics and non-steroidal anti-inflammatories.

1 . A method of treating presbyopia comprising topically treating a patient in need thereof with a composition comprising a combination of a parasympathomimetic or a salt thereof and a non-steroidal anti-inflammatory drug or a salt thereof. 
     
     
         2 . The method of  claim 1 , wherein the parasympathomimetic agent is pilocarpine or a salt thereof. 
     
     
         3 . The method of  claim 2 , wherein the parasympathomimetic agent is pilocarpine hydrochloride. 
     
     
         4 . The method of  claim 2 , wherein the non-steroidal anti-inflammatory drug is selected from a group consisting of diclofenac, ketorolac, bromfenac, flurbiprofen, suprofen, pranoprofen, oxyphenbutazone, bendazac, and indomethacin. 
     
     
         5 . The method of  claim 4 , wherein the non-steroidal anti-inflammatory drug is diclofenac or a salt thereof. 
     
     
         6 . The method of  claim 1 , wherein the non-steroidal anti-inflammatory drug is selected from a group consisting of diclofenac, ketorolac, bromfenac, flurbiprofen, suprofen, pranoprofen, oxyphenbutazone, bendazac, and indomethacin. 
     
     
         7 . The method of  claim 6 , wherein the parasympathomimetic agent is pilocarpine hydrochloride. 
     
     
         8 . The method of  claim 1 , wherein the composition comprises pilocarpine or a salt thereof in concentrations ranging from 1% to 2% and diclofenac or a salt thereof in an amount ranging from 0.1% to 0.5%. 
     
     
         9 . The method of  claim 1 , wherein the parasympathomimetic agent or a salt thereof is 0.5% to 4% of the composition and the non-steroidal anti-inflammatory drug or a salt thereof is 0.01 mg to 0.1 mg of the composition.