Mesenchymal stem cell and a method of use thereof

Abstract

Demyelinated axons were remyelinated in the demyelinated rat model by collecting bone marrow cells from mouse bone marrow and transplanting the mononuclear cell fraction separated from these bone marrow cells.

1 - 16 . (canceled) 
     
     
         17 . A cell population isolated from bone marrow or cord blood comprising
 mesenchymal stem cells that are SH2(+), SH3(+), SH4(+), CD29(+), CD44(+), CD14(−), CD34(−), and CD45(−),   wherein cells within said cell population differentiate into neurons or glia cells after transplantation into a patient.   
     
     
         18 . A method for treating neurodegeneration, comprising
 isolating the cell population of claim  1 , wherein said isolation does not exclude hematopoietic cells from said cell population; and   injecting an effective amount of said isolated cell population into a patient in need of said treatment,   wherein said effective amount of said isolated cell population is effective at treating said patient's neurodegeneration.   
     
     
         19 . The method for treating neurodegeneration according to  claim 18 , wherein said neurodegeneration is caused by nerve demyelination. 
     
     
         20 . The method for treating neurodegeneration according to  claim 18 , wherein said cell population is injected intra-arterially. 
     
     
         21 . The method for treating neurodegeneration according to  claim 18 , wherein said cell population is injected intravenously. 
     
     
         22 . The method for treating neurodegeneration according to  claim 21 , wherein said cell population is injected into the carotid artery. 
     
     
         23 . The method for treating neurodegeneration according to  claim 18 , wherein cells within said injected cell population differentiate into neuron or glia cells at a site of neurodegeneration. 
     
     
         24 . The method for treating neurodegeneration according to  claim 18 , wherein said neurodegeneration is caused by ischemia. 
     
     
         25 . The method for treating neurodegeneration according to  claim 24 , wherein said neurodegeneration caused by ischemia is stroke. 
     
     
         26 . The method for treating neurodegeneration according to  claim 18 , wherein said neurodegeneration is caused by demyelination or trauma. 
     
     
         27 . The method for treating neurodegeneration according to  claim 26 , wherein said trauma is caused by spinal cord injury or brain injury. 
     
     
         28 . The method for treating neurodegeneration according to  claim 26 , wherein said demyelination is caused by spinal cord injury or multiple sclerosis. 
     
     
         29 . The method for treating neurodegeneration according to  claim 18 , wherein said neurodegeneration is associated with Alzheimer's disease, Parkinson's disease, Huntington's disease, or amyotrophic lateral sclerosis (ALS).