Methods Of Treating Autism With mGluR5 Antagonists

Abstract

mGluR5 antagonists are used for the treatment of autism. The human treated by the methods of the invention can also have fragile X syndrome, epilepsy and anxiety.

What is claimed is: 
     
         1 . A method of treating autism in a human, comprising the step of orally administering to the human a composition that includes a mGluR5 antagonist, wherein the mGluR5 antagonist is administered to the human at a dose of about 10 mg/kg body weight. 
     
     
         2 . The method of  claim 2 , wherein the human further has fragile X syndrome. 
     
     
         3 . The method of  claim 2 , wherein the human further has a seizure disorder. 
     
     
         4 . The method of  claim 3 , wherein the seizure disorder includes epilepsy. 
     
     
         5 . The method of  claim 2 , wherein the human further has an anxiety disorder. 
     
     
         6 . The method of  claim 2 , wherein the human further has a deficit in sociability. 
     
     
         7 . The method of  claim 2 , wherein the human further has a deficit in a reciprocal verbal and nonverbal communication. 
     
     
         8 . The method of  claim 2 , wherein the human further has a repetitive behavior disorder. 
     
     
         9 . The method of  claim 2 , wherein the mGluR5 antagonist is administered twice a day to the human.