Pharmaceutical product with closure assembly

Abstract

A system includes a container and an adapter. The container may include a wall defining a receptacle and a neck, the neck forming an opening and a passage in fluid communication between the receptacle and the opening; a closure assembly having a portion disposed within the neck, and including an insert defining a valve seat, an actuator, a valve member attached to the actuator and sealingly engageable with the valve seat, and a biasing member disposed between the insert and the actuator. The biasing member urges the valve member into sealing engagement with the valve seat in an actuator advanced state, and the valve member disengages from the valve seat in an actuator retracted state, the actuator depending through the opening in the advanced state. The adapter may be removably attached to the container, and configured to move the actuator from advanced to retracted state upon attachment.

What is claimed is: 
     
         1 . A system comprising:
 a container including:
 a wall defining a receptacle and a neck, the neck forming an opening and a passage in fluid communication between the receptacle and the opening; and 
 a closure assembly having a portion disposed within the neck, the closure assembly comprising an insert defining a valve seat, an actuator, a valve member attached to the actuator and sealingly engageable with the valve seat, and a biasing member disposed between the insert and the actuator, 
 wherein the biasing member urges the valve member into sealing engagement with the valve seat when the actuator is in an advanced state, and the valve member disengages from the valve seat with the actuator in a retracted state, the actuator depending through the opening in the advanced state; and 
   an adapter removably attachable to the container, the adapter configured to cooperate with a vaporizer inlet port and to move the actuator from the advanced state to the retracted state upon attachment of the adapter to the container.   
     
     
         2 . The system of  claim 1 , wherein:
 the valve seat is defined at a proximal end of the insert,   the valve member is attached to a proximal end of the actuator;   a distal end of the actuator depends through the opening in the advanced state; and   the biasing member is disposed between the distal end of the actuator and the proximal end of the insert.   
     
     
         3 . The system of  claim 2 , wherein the insert includes a radially inwardly directed rim, and the biasing member is disposed between the distal end of the actuator and the radially inwardly directed rim. 
     
     
         4 . The system of  claim 3 , wherein the proximal end of the actuator depends into the insert, and a distal end of the valve member is attached to the proximal end of the actuator while a proximal end of the valve member sealingly engages the valve seat in the advanced state. 
     
     
         5 . The system of  claim 1 , wherein the biasing member comprises a compression spring. 
     
     
         6 . The system of  claim 1 , wherein the actuator has at least one annular wall and a central mounting hub to which the valve member is attached, the mounting hub spaced from an inner surface of the annular wall to define one or more passages therebetween. 
     
     
         7 . The system of  claim 6 , wherein an end of the biasing member is received about the mounting hub to align the biasing member. 
     
     
         8 . The system of  claim 1 , wherein the insert comprises a sink, and an end of the biasing member is disposed within the sink to align the biasing member. 
     
     
         9 . The system of  claim 1 , wherein the valve member comprises a poppet valve head. 
     
     
         10 . The system of  claim 1 , wherein the valve member comprises a valve head including a groove and a flexible sealing member received within the groove. 
     
     
         11 . The system of  claim 1 , wherein the valve member is formed integrally with the actuator. 
     
     
         12 . The system of  claim 1 , further comprising a halogenated inhalation anesthetic disposed within the receptacle, the halogenated inhalation anesthetic being selected from the group consisting of sevoflurane, desflurane, isoflurane, enflurane, methoxyflurane and halothane. 
     
     
         13 . The system of  claim 1 , wherein the insert is press-fit into the neck passage. 
     
     
         14 . The system of  claim 1 , wherein the container comprises a shoulder formed in the passage, and the insert comprises a shoulder formed in an exterior surface of the insert, the shoulders abutting to limit movement of the insert relative to the container along the passage. 
     
     
         15 . The system of  claim 1 , wherein the container comprises a collar disposed about passage, the collar having a threaded region for threadingly engaging an adapter configured to cooperate with a vaporizer inlet port and to cooperate with the actuator to move the actuator between the advanced and retracted states.