Devices, Systems and Methods for Closure of Cardiac Openings

Abstract

The invention generally relates to devices, systems, and methods for percutaneous closure of cardiac openings and obliteration of the cardiac cul-de-sacs. In one embodiment, a closure device includes a patch with an adhesive and/or a removable frame. The patch may be placed across a cardiac opening, such as a patent foramen ovale, or across a cardiac cul-de-sac, such as a left atrial appendage. In another embodiment, a closure device includes a balloon together with adhesives and/or substances for stimulating tissue growth coated on, or contained within, the balloon. The balloon may be inserted into a cardiac opening, such as the patent foramen ovale, or into a cardiac cul-de-sac, such as a left atrial appendage.

What is claimed is: 
     
         1 . A system for percutaneous transvascular closure of an intra-cardiac opening in a patient, comprising:
 a catheter comprising a distal end;   a patch defining at least one hollow channel, said patch sized and shaped for percutaneous transvascular delivery to an intracardiac anatomical site and releasably joined to the distal end of the catheter; and   an adhesive for adhering said patch over said intracardiac opening.   
     
     
         2 . The system of  claim 1 , wherein the patch comprises a bioresorbable material. 
     
     
         3 . The system of  claim 1 , wherein the adhesive comprises a light activated adhesive. 
     
     
         4 . The system of  claim 3 , wherein the light activated adhesive comprises an adhesive curable with ultraviolet light. 
     
     
         5 . The system of  claim 1 , wherein the hollow channel comprises a conduit for light. 
     
     
         6 . The system of  claim 1  further comprising a fiber optic cable enclosed within the hollow channel. 
     
     
         7 . The system of  claim 1  further comprising a frame enclosed within the hollow channel. 
     
     
         8 . The system of  claim 1  further comprising a divider having first and second surfaces, wherein the first surface is coupled to the adhesive and the second surface is coated with a primer. 
     
     
         9 . The system of  claim 1  further comprising a housing. 
     
     
         10 . The system of  claim 9 , wherein the housing is substantially conically shaped. 
     
     
         11 . The system of  claim 9  further comprising a light source, wherein the light source is enclosed within the housing. 
     
     
         12 . The system of  claim 11 , wherein the light source comprises a light-conducting medium. 
     
     
         13 . The system of  claim 12 , wherein the light source comprises a fiber optic cable. 
     
     
         14 . The system of  claim 9  further comprising a divider comprising first and second surfaces, wherein the first surface is in contact with the adhesive and the second surface is coated with a primer. 
     
     
         15 . The system of  claim 1  further comprising a frame wherein at least a portion of the frame is positioned within the hollow channel. 
     
     
         16 . The system of  claim 1 , wherein the patch comprises collagen. 
     
     
         17 . The system of  claim 15 , wherein the frame comprises a shape memory alloy. 
     
     
         18 . A closure device for percutaneous transvascular closure of a patent foramen ovale in a patient, comprising:
 a U-shaped patch configured for attachment to the septum secundum of the patent foramen ovale; and   an adhesive coating on the U-shaped patch, wherein the adhesive-coated U-shaped patch closes the patent foramen ovale when attached to the septum secundum.   
     
     
         19 . The device of  claim 18 , further comprising a stimulator for stimulating tissue in-growth into the closure device, wherein the stimulator is coated on said U-shaped patch. 
     
     
         20 . The device of  claim 19 , wherein the stimulator comprises a growth factor. 
     
     
         21 . The device of  claim 19 , wherein the stimulator comprises a pharmacological agent to stimulate tissue growth. 
     
     
         22 . The device of  claim 19 , wherein the stimulator comprises an irritant to encourage an inflammatory response. 
     
     
         23 . The device of  claim 19 , wherein the stimulator comprises cells. 
     
     
         24 . The device of  claim 19 , wherein the stimulator comprises a gene. 
     
     
         25 . The device of  claim 18  further comprising at least one barrier coupled to the U-shaped patch. 
     
     
         26 . The device of  claim 25 , wherein the barrier is a right atrial barrier for blocking an opening to the patent foramen ovale from the right atrium. 
     
     
         27 . The device of  claim 25 , wherein the barrier is a left atrial barrier for blocking an opening to the patent foramen ovale from the left atrium. 
     
     
         28 . The device of  claim 18 , wherein the U-shaped patch comprises a material selected from the group consisting of a biological material, a bioresorbable material, a synthetic material, a polymeric material, a shape memory material, and a metallic mesh material. 
     
     
         29 . The device of  claim 18 , wherein the adhesive comprises cyanoacrylate. 
     
     
         30 . The device of  claim 18 , wherein the adhesive comprises a fibrin based adhesive.