US2013149349A1PendingUtilityA1

Use of compounds with thrombopoietic activity to promote bone growth and healing

47
Individually held — no corporate assignee on recordPriority: Jun 3, 2010Filed: Jun 3, 2011Published: Jun 13, 2013
Est. expiryJun 3, 2030(~3.8 yrs left)· nominal 20-yr term from priority
Inventors:Melissa A. KacenaTien-Min Gabriel Chu
A61K 45/06C07K 14/524A61K 38/196A61P 19/00A61L 27/54C07K 2319/30A61K 9/0024
47
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Claims

Abstract

TPO was used to promote the growth of bone in both rats and in mice. Gaps in both mouse and in rat bones were treated with a scaffold sized to fit the gap. Scaffolds that included TPO promoted better outcomes than scaffolds that included BMP-2 or scaffolds that did not include either TPO or BMP-2. These data indicate that compounds that exhibit thrombopoietic activity such a recombinant TPO can be used to promote bone growth and healing in mammals.

Claims

exact text as granted — not AI-modified
We claim: 
     
         1 . A method for treating bone comprising the steps of:
 treating at least one portion of a living bone with at least one exogenous compound that exhibits thrombopoietic activity.   
     
     
         2 . The method according to  claim 1 , wherein the compound that exhibits thrombopoietic activity is TPO. 
     
     
         3 . The method according to  claim 1 , wherein the compound that exhibits thrombopoietic activity is romiplostim or a romiplostim like compound. 
     
     
         4 . The method according to  claim 1 , wherein the first compound that exhibits thrombopoietic activity is megakaryocyte growth and development factor. 
     
     
         5 . The method according to  claim 1 , further including the step of:
 providing at least one second compound that is useful for the treatment of living bone.   
     
     
         7 . The method according to  claim 1 , wherein the contacting step occurs in vivo. 
     
     
         8 . The method according to  claim 1 , wherein the contacting step occurs in vitro. 
     
     
         9 . The method according to  claim 1 , wherein exhibits thrombopoietic activity is included in at least one formulation selected from the group consisting of; a paste, a glue, a coating, a gel, a powder and a liquid. 
     
     
         10 . A device for treating bone defects, comprising:
 at least one physical support and   at least one compound that exhibits thrombopoietic activity.   
     
     
         11 . The device according to  claim 10 , wherein the device is biodegradable. 
     
     
         12 . The device according to  claim 10 , wherein the device is a scaffold. 
     
     
         13 . The device according to  claim 10 , wherein the first compound is TPO. 
     
     
         14 . The method according to  claim 10 , wherein the first compound is romiplostim. 
     
     
         15 . The method according to  claim 10 , wherein the first compound is megakaryocyte growth and development factor. 
     
     
         16 . The method according to  claim 10 , wherein the compound exhibiting is included in at least one formulation selected from the group consisting of; a paste, a glue, a coating, a gel, a powder and a liquid. 
     
     
         17 . A method of treating a bone defect, comprising the steps of:
 identifying a bone defect;   providing a biodegradable device, wherein said device includes at least one compound that exhibits thrombopoietic activity; and   contacting said biodegradable device with the bone defect.   
     
     
         18 . The method according to  claim 17 , wherein said biodegradable device is a scaffold. 
     
     
         19 . The method according to  claim 17 , wherein the bone defect is in an animal. 
     
     
         20 . The method according to  claim 17 , wherein the bone defect is in human. 
     
     
         21 . The method according to  claim 17 , wherein the device includes at least one additional compound that promotes bone growth. 
     
     
         22 . The method according to  claim 17 , wherein the device includes at least one additional compound that inhibits infection. 
     
     
         23 . The method according to  claim 17 , wherein the device includes at least one anchor for attaching the device to the bone.

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