Needless microprotrusion elastoplast system

Abstract

A needleless microprotrusion system for infusion of a medicament into a patient includes a plurality of microprotrusions having a length sufficient to penetrate a stratum corneum of the patient. A chemodenervating agent is disposed for delivery by the microprotrusions and a substrate is provided for supporting the microprotrusions and conforming the microprotrusions to a patient's fossa axilaaris in order to enable uniform penetration of the microprotrusions into the corneum.

What is claimed is: 
     
         1 . A needleless microprotrusion system for infusion of a medicament into a patient, the system comprising:
 a plurality of microprotrusions having a length sufficient to penetrate a stratum corneum of the patient;   a chemodenervating agent disposed on penetrating surfaces of the microprotrusions;   a substrate for supporting the microprotrusions, said substrate having a U-shape for conforming to a patients' fossa axillaris in order to enable uniform penetration of the microprotrusions into the fossa axillaris stratum corneum.   
     
     
         2 . The system according to  claim 1  further comprising an adhesive disposed on said substrate for temporary adhering said substrate to a patients skin. 
     
     
         3 . The system according to  claim 2  wherein said adhesive surrounds said microprotrusion. 
     
     
         4 . The system according to  claim 3  wherein said substrate is flexible. 
     
     
         5 . The system according to  claim 4  wherein said chemodenervating agent is coated on said microprotrusion. 
     
     
         6 . The system according to  claim 5  wherein said chemodenervating agent comprises botulinum toxin. 
     
     
         17 . A method for delivering a medicament a patient's fossa axillaris, said method comprising:
 providing a substrate having a U-shape for conforming to the patient's fossa axillaris, said substrate having microprotrusions disposed one side of said substrate, said microprotrusion having a length sufficient to penetrate a stratum corneum of the patients' fossa axillaris;   providing a chemodenervating agent for delivering by said microprotrusion;   coating the chemodenervating agent on penetrating surfaces of the microprotrusions; and   instructing said patient to dispose said substrate in the fossa axillaris.   
     
     
         8 . The method according to claim  7  wherein said chemodenervating agent comprises botulinum toxin. 
     
     
         9 . The method according to  claim 8  further comprises providing a flexible substrate.