US2013136783A1PendingUtilityA1

Hydrophilized antimicrobial polymers

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Assignee: PURDUE RESEARCH FOUNDATIONPriority: Aug 24, 2005Filed: Jan 23, 2013Published: May 30, 2013
Est. expiryAug 24, 2025(expired)· nominal 20-yr term from priority
Inventors:Jeffrey P. YoungbloodPhilippe H. SellenetThomas R. Stratton
C12Q 1/18A01N 43/40C08F 26/06C08F 226/06
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Claims

Abstract

A bactericidal or antimicrobial polymeric composition includes a hydrophilic first comonomer copolymerized to a second comonomer to produce a polymeric composition that is more hydrophilic or more bactericidal or antimicrobial in an aqueous solution than either of the comonomers alone. Methods for identifying bactericidal or antimicrobial polymers, methods for rendering materials bactericidal or antimicrobial, and methods for using bactericidal or antimicrobial compositions to kill or reduce bacterial or microbial growth are also described. Applications for the inventive compositions include their use in catheters, stents, medical devices, contact lenses; root canal fillers; fibers; paper; and/or wound dressing.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A device comprising a substrate having thereon a polymer represented as a free-radical copolymerization product of
 (a) a first monomer comprising a hydrophilic monomer having an acrylate group   (b) a second monomer comprising at least one monomer selected from a pyridinium-type monomer having a quaternized nitrogen and a pyridine-type monomer having a nitrogen quaternizable with an alkyl halide, the second monomer additionally having a vinyl group   (c) said polymer in quaternized form being more bactericidal in an aqueous solution than the first monomer or a homopolymer formed from the first monomer, and said polymer being more bactericidal in an aqueous solution than the second monomer or a homopolymer formed from the second monomer.   
     
     
         2 . A device according to  claim 1 , wherein the second monomer comprises a member of the group consisting of vinylpyridine and quaternized vinylpyridinium. 
     
     
         3 . A device according to  claim 1 , wherein the first monomer comprises at least one selected from hydroxyethylmethacylate, polyethylene glycol) rnethacrylate and polyethylene glycol) methyl ether methacrylate. 
     
     
         4 . A device according to  claim 3 , wherein the second monomer comprises a member of the group consisting of vinylpyridine and quaternized vinylpyridinium. 
     
     
         5 . A device according to  claim 4  wherein said second monomer comprises the quaternized vinylpyridinium and said nitrogen is quaternized with an alkyl group. 
     
     
         6 . A device according to  claim 5  further comprising a halide anion associated with the quaternized nitrogen of the vinylpyridinium. 
     
     
         7 . A device according to  claim 6  wherein the anion comprises a bromide anion. 
     
     
         8 . A device according to  claim 5  wherein the alkyl group comprises a hexyl group. 
     
     
         9 . A device according to  claim 8  further comprising a halide anion associated with the quaternized nitrogen of said vinylpyridinium. 
     
     
         10 . A device according to  claim 9  wherein the halide anion comprises a bromide anion. 
     
     
         11 . A device according to  claim 4  wherein the first monomer comprises poly(ethylene glycol) methacrylate having a molecular weight of at least about 300 Daltons. 
     
     
         12 . A device according to  claim 11  wherein the molecular weight of said poly(ethylene glycol) methacrylate is less than about 2000 Daltons. 
     
     
         13 . A device according to  claim 4  wherein said polymer contains at least about 1 mol percent of at least one selected from said poly(ethylene glycol) methacrylate and said poly(ethylene glycol) methyl ether methacrylate. 
     
     
         14 . A device according to  claim 4  wherein the first monomer comprises poly(ethylene glycol) methyl ether methacrylate. 
     
     
         15 . A device according to  claim 14  wherein said second monomer comprises the quaternized vinylpyridinium and said nitrogen is quaternized with a hexyl group. 
     
     
         16 . A device according to  claim 14  wherein said second monomer comprises the quaternized vinylpyridinium and further comprising a bromide anion associated with the quaternized nitrogen of said vinylpyridinium. 
     
     
         17 . A device according to  claim 15  further comprising a bromide anion associated with the quaternized nitrogen of said vinylpyridinium. 
     
     
         18 . A device according to  claim 1  wherein the polymer is a random polymer. 
     
     
         19 . A device according to  claim 1  wherein the polymer is a block polymer. 
     
     
         20 . A device according to  claim 1  wherein the substrate comprises a medical device. 
     
     
         21 . A device according to  claim 20  wherein the medical device is selected from a catheter, a needle, a tissue culture plate, and an implantable medical device. 
     
     
         22 . A device according to  claim 1  wherein the substrate comprises a dressing. 
     
     
         23 . A device according to  claim 1  wherein the substrate comprises a contact lens. 
     
     
         24 . A device according to  claim 1  wherein the substrate comprises a transparent substrate. 
     
     
         25 . A device according to  claim 1  wherein the substrate comprises paper. 
     
     
         26 . A device according to  claim 1  wherein the substrate comprises fibers. 
     
     
         27 . A device according to  claim 4  wherein the substrate comprises a medical device. 
     
     
         28 . A device according to  claim 27  wherein the medical device is selected from a catheter, a needle, a tissue culture plate, and an implantable medical device. 
     
     
         29 . A device according to  claim 4  wherein the substrate comprises a dressing. 
     
     
         30 . A device according to  claim 4  wherein the substrate comprises a contact lens. 
     
     
         31 . A device according to  claim 4  wherein the substrate comprises a transparent substrate. 
     
     
         32 . A device according to  claim 4  wherein the substrate comprises paper. 
     
     
         33 . A device according to  claim 4  wherein the substrate comprises fibers. 
     
     
         34 . A device according to  claim 4  wherein the substrate is formed of said polymer.

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