Tumor proliferation inhibitor containing ultrasound-sensitive substance and method for inhibiting tumor proliferation by using tumor proliferation inhibitor and low-intensity pulsed ultrasound waves

Abstract

Provided are a tumor proliferation inhibitor and a method for inhibiting tumor proliferation both of which can be applied to a minimally invasive cancer treatment using low-intensity pulsed ultrasound. The present invention provides a tumor proliferation inhibitor containing an ultrasound-sensitive substance and an acoustic cavitation phenomenon-enhancing substance, and provides a method for inhibiting tumor proliferation that can exhibit a tumor proliferation-inhibitory effect using the tumor proliferation inhibitor in combination with low-intensity pulsed ultrasound of a degree that is used in ultrasound diagnosis, and that can be applied to a minimally invasive cancer treatment using low-intensity pulsed ultrasound.

1 - 6 . (canceled) 
     
     
         7 . A tumor proliferation inhibitor containing an ultrasound-sensitive substance substantially unreactive with a light and an acoustic cavitation phenomenon-enhancing substance. 
     
     
         8 . The tumor proliferation inhibitor as claimed in  claim 7 , wherein said ultrasound-sensitive substance is a porphyrin derivative or a xanthene derivative. 
     
     
         9 . The tumor proliferation inhibitor as claimed in  claim 8 , wherein said porphyrin derivative is [7,12-bis(1-(2-(2-hydroxyethoxy)ethoxy)ethyl)-3,8,13, 17-tetramethyl-porphyrin-2,18-dipropionato]manganese (DEG) as represented by formula [I]: 
       
         
           
           
               
               
           
         
       
       or 3,17-bis(1-carboxyethyl)-8-[2-(2,4-dichlorophenyl-hydrazono) ethylidene]-3-ethenyl-7-hydroxy-2,7,12,18-tetramethylchlorin disodium salt as represented by formula [II]: 
       
         
           
           
               
               
           
         
       
     
     
         10 . The tumor proliferation inhibitor as claimed in  claim 7 , wherein said acoustic cavitation phenomenon-enhancing substance is gas-filled bubbles. 
     
     
         11 . The tumor proliferation inhibitor as claimed in  claim 10 , wherein said gas-filled bubbles are microbubbles or nanobubbles. 
     
     
         12 . The tumor proliferation inhibitor as claimed in  claim 10 , wherein said gas-filled bubbles are sonazoid or levovist. 
     
     
         13 . A method for the treatment of cancers using a tumor proliferation inhibitor containing an ultrasound-sensitive substance substantially unreactive with a light and an acoustic cavitation phenomenon-enhancing substance. 
     
     
         14 . The method as claimed in  claim 13 , wherein said ultrasound-sensitive substance is a porphyrin derivative or a xanthene derivative. 
     
     
         15 . The method as claimed in  claim 14 , wherein said porphyrin derivative is [7,12-bis(1-(2-(2-hydroxyethoxy)ethoxy)ethyl)-3,8,13,17-tetramethylporphyrin-2, 18-dipropionato]manganese (DEG) as represented by formula [I]: 
       
         
           
           
               
               
           
         
       
       or 3,17-bis(1-carboxyethyl)-8-[2-(2,4-dichlorophenyl-hydrazono) ethylidene]-3-ethenyl-7-hydroxy-2,7,12,18-tetramethylchlorin disodium salt as represented by formula [II]: 
       
         
           
           
               
               
           
         
       
     
     
         16 . The method as claimed in  claim 13 , wherein said acoustic cavitation phenomenon-enhancing substance is gas-filled bubbles. 
     
     
         17 . The method as claimed in  claim 16 , wherein said gas-filled bubbles are microbubbles or nanobubbles. 
     
     
         18 . The method as claimed in  claim 16 , wherein said gas-filled bubbles are sonazoid or levovist.