US2013123318A1PendingUtilityA1

Anti-fungal formulation

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Assignee: Topica PharmaceuticalsPriority: Feb 13, 2009Filed: Dec 20, 2012Published: May 16, 2013
Est. expiryFeb 13, 2029(~2.6 yrs left)· nominal 20-yr term from priority
Inventors:Charles G. VontzNorifumi NakamuraCatherine De Porceri-MortonJeff HughesBhavesh ShahPeter GertasVitthal Kulkarni
A61P 31/10A61K 31/4178A61K 47/08A61P 17/00A61K 47/10A61K 47/14
51
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Claims

Abstract

Provided herein are compositions and formulations comprising an antifungal agent. Pharmaceutical compositions comprising luliconazole in an amount effective for the treatment of onychomycosis are provided. Also provided are methods for treating dermatomycoses and onychomycosis using the compositions and formulations.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A pharmaceutical composition, comprising:
 from 5 weight percent to 15 weight percent luliconazole;   from 5 weight percent to 25 weight percent acetone;   from 1 weight percent to 15 weight percent propylene carbonate;   from 15 weight percent to 35 weight percent of an ethylene glycol derivative of the formula HOCH 2 CH 2 OCH 2 CH 2 OR where R is an alkyl group having 1 to 6 carbon atoms; and   from 0.01 weight percent to 6 weight percent benzyl alcohol.   
     
     
         2 . The composition of  claim 1 , wherein R is ethyl. 
     
     
         3 . The composition of  claim 1 , wherein the composition comprises 2 weight percent to 4 weight percent benzyl alcohol. 
     
     
         4 . The composition of  claim 1 , wherein the composition further comprises a film forming agent in from 0.01 weight percent to 4 weight percent. 
     
     
         5 . The composition of  claim 4 , wherein the film-forming agent is a maleic anhydride/methyl vinyl ether copolymer. 
     
     
         6 . The composition of  claim 4 , wherein the film forming agent is Gantrez® ES-425. 
     
     
         7 . The composition of  claim 1 , wherein the composition further comprises ethanol. 
     
     
         8 . The composition of  claim 7 , wherein the composition comprises from 35 weight percent to 45 weight percent ethanol. 
     
     
         9 . The composition of  claim 1 , wherein the composition comprises:
 from 9 weight percent to 12.5 weight percent luliconazole;   from 8 weight percent to 15 weight percent acetone;   from 3 weight percent to 8 weight percent propylene carbonate;   from 20 weight percent to 30 weight percent of an ethylene glycol derivative of the formula HOCH 2 CH 2 OCH 2 CH 2 OR where R is an alkyl group having 1 to 6 carbon atoms; and   benzyl alcohol from 0.01 weight percent to 5 weight percent.   
     
     
         10 . The composition of  claim 9 , wherein R is ethyl. 
     
     
         11 . The composition of  claim 9 , wherein the composition comprises 2 weight percent to 4 weight percent benzyl alcohol. 
     
     
         12 . The composition of  claim 1 , wherein the composition further comprises a film forming agent in from 0.01 weight percent to 4 weight percent. 
     
     
         13 . The composition of  claim 12 , wherein the film-forming agent is a maleic anhydride/methyl vinyl ether copolymer. 
     
     
         14 . The composition of  claim 12 , wherein the film forming agent is Gantrez® ES-425. 
     
     
         15 . The composition of  claim 9 , wherein the composition further comprises ethanol. 
     
     
         16 . The composition of  claim 15 , wherein the composition comprises from 35 weight percent to 45 weight percent ethanol. 
     
     
         17 . The composition of  claim 1 , wherein the composition comprises 10 weight percent luliconazole. 
     
     
         18 . The composition of  claim 1 , wherein the composition comprises 12.5 weight percent luliconazole. 
     
     
         19 . The composition of  claim 9 , comprising:
 10 weight percent luliconazole;   12 weight percent acetone;   5 weight percent propylene carbonate;   25 weight percent of an ethylene glycol derivative of the formula HOCH 2 CH 2 OCH 2 CH 2 OR where R is ethyl; and   4 weight percent benzyl alcohol.   
     
     
         20 . The composition of  claim 19 , wherein the composition further comprises a film forming agent in 1 weight percent. 
     
     
         21 . The composition of  claim 20 , wherein the film-forming agent is a maleic anhydride/methyl vinyl ether copolymer. 
     
     
         22 . The composition of  claim 21 , wherein the film forming agent is Gantrez® ES-425. 
     
     
         23 . The composition of  claim 19 , wherein the composition further comprises ethanol.

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