US2013102832A1PendingUtilityA1

Brachytherapy devices and related methods having microencapsulated brachytherapy materials

27
Individually held — no corporate assignee on recordPriority: Aug 25, 2011Filed: Aug 24, 2012Published: Apr 25, 2013
Est. expiryAug 25, 2031(~5.1 yrs left)· nominal 20-yr term from priority
Inventors:Seth A. HoedlBruce Kitzman
A61N 5/1001A61N 2005/1024A61N 2005/1023
27
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

A brachytherapy device includes a bioabsorbable support and a plurality of microcapsules on the support. Each of the plurality of the microcapsules includes a plurality of microspheres and a bioabsorbable microcapsule wall that encloses the plurality of microspheres. The plurality of microspheres includes radiation-emitting microspheres comprising a radioactive material, radio-opaque microspheres comprising a radio-opaque material or a combination thereof.

Claims

exact text as granted — not AI-modified
That which is claimed is: 
     
         1 . A low-dose-rate (LDR) brachytherapy device comprising:
 a bioabsorbable support;   a plurality of microcapsules on the support, each of the plurality of a microcapsules comprising a plurality of microspheres and a bioabsorbable microcapsule wall that encloses the plurality of microspheres, wherein the plurality of microspheres comprises radiation-emitting microspheres comprising a radioactive material, radio-opaque microspheres comprising a radio-opaque material or a combination thereof.   
     
     
         2 . The device of  claim 1 , wherein the plurality of microspheres have a diameter of about 1 to 20 microns. 
     
     
         3 . The device of  claim 2 , wherein the plurality of microspheres are sized and configured so as to be subject to phagocytosis by macrophages in a subject after bioabsorption of the bioabsorbable support and the bioabsorbable microcapsule wall. 
     
     
         4 . The device of  claim 3 , wherein the bioabsorbable support and the microcapsule wall have a decay time that is greater than about two and a half times a half life of the radioactive material. 
     
     
         5 . The device of  claim 1 , wherein some of the plurality of microspheres comprise a radioactive core and an outer wall. 
     
     
         6 . The device of  claim 5 , wherein the radioactive core comprises a radioactive material and a biocompatible polymer and/or ceramic. 
     
     
         7 . The device of  claim 1 , wherein some of the plurality of microspheres comprise a porous material and a radio-isotope deposited therein. 
     
     
         8 . The device of  claim 5 , wherein the outer wall comprises glass or acrylic. 
     
     
         9 . The device of  claim 1 , wherein the microcapsule wall comprises a poly-lactide, poly-glycolide, polycaprolactone, poly-trimethylene-carbonate, polyanhdride, co-polymers formed thereof, and/or combinations thereof. 
     
     
         10 . The device of  claim 1 , wherein the bioabsorbable support comprises a poly-lactide, poly-glycolide, polycaprolactone, poly-trimethylene-carbonate, polyanhdride, co-polymers formed thereof, and/or combinations thereof. 
     
     
         11 . The device of  claim 1 , wherein the bioabsorbable support is configured to seal the microcapsules therein after implantation. 
     
     
         12 . The device of  claim 11 , wherein a size and/or thickness of the bioabsorbable support and/or microcapsule walls is configured to release the microspheres after a predetermined time. 
     
     
         13 . The device of  claim 12 , wherein the predetermined time is greater than two and a half times a half life of the radioactive material. 
     
     
         14 . The device of  claim 12 , wherein the predetermined time is about three months. 
     
     
         15 . The device of  claim 1 , wherein the bioabsorbable support comprises a seed casing that is configured to seal the plurality of microcapsules therein prior to bioabsorption of the support. 
     
     
         16 . The device of  claim 1 , wherein the bioabsorbable support comprises a substantially linear support having a plurality of wells therein that is configured to seal the plurality of microcapsules in respective ones of the plurality of wells prior to bioabsorption of the support. 
     
     
         17 . The device of  claim 1 , wherein the bioabsorbable support comprises a substantially planar support that is configured to seal the plurality of microcapsules therein prior to bioabsorption of the support. 
     
     
         18 . A microcapsule comprising:
 a microcapsule outer wall;   a plurality of microspheres enclosed by the microcapsule outer wall, wherein the plurality of microspheres comprises radiation-emitting microspheres comprising a radioactive material, radio-opaque microspheres comprising a radio-opaque material or a combination thereof.   
     
     
         19 . The microcapsule of  claim 18 , wherein the plurality of microspheres have a diameter of about 1 to 20 microns. 
     
     
         20 . The microcapsule of  claim 19 , wherein the plurality of microspheres are sized and configured so as to be subject to phagocytosis by macrophages in a subject after bioabsorption of the bioabsorbable support and the bioabsorbable microcapsule wall. 
     
     
         21 . The microcapsule of  claim 18 , wherein some of the plurality of microspheres comprises a radioactive core and an outer wall. 
     
     
         22 . The microcapsule of  claim 21 , wherein the radioactive core comprises a radioactive material and a biocompatible polymer and/or ceramic. 
     
     
         23 . The microcapsule of  claim 18 , wherein some of the plurality of microspheres comprise a porous material and a radio-isotope deposited therein. 
     
     
         24 . The microcapsule of  claim 21 , wherein the outer wall comprises glass or acrylic. 
     
     
         25 . The microcapsule of  claim 18 , wherein the microcapsule wall comprises a poly-lactide, poly-glycolide, polycaprolactone, poly-trimethylene-carbonate, polyanhdride, co-polymers formed thereof, and/or combinations thereof.

Join the waitlist — get patent alerts

Track US2013102832A1 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.