Cyanoacrylate Adhesive Compositions, Methods of Sterilization of the Compositions, and Articles of Manufacture Containing Such Compositions

Abstract

The viscosities of 2-cyanoacrylate adhesive compositions are adjusted by the addition of polymeric thickeners to a preferred initial viscosity that will not increase significantly when sterilized by heating them at a temperature of no greater than about 110° C. for no more than about 120 minutes. Articles of manufacture are vials or squeezable tubes containing these compositions.

1 . A cyanoacrylate adhesive composition, comprising:
 at least one 2-cyanoacrylate monomer; and   at least one polymeric thickener in an amount   
       establishing an initial viscosity that will not significantly increase when the composition is sterilized at a temperature no greater than approximately 110° C. for a period of time sufficient to sterilize the composition. 
     
     
         2 . The composition of  claim 1 , in which:
 said initial viscosity is in the range of about 400 to about 600 centipoises.   
     
     
         3 . The composition of  claim 1 , in which:
 said period of time is no greater than about 120 minutes.   
     
     
         4 . An article of manufacture, comprising:
 a container
 packed with a mixture of
 at least one 2-cyanoacrylate monomer; and 
 at least one polymeric thickener in an amount establishing a viscosity that will not significantly increase when the mixture is sterilized; 
 
 the container then being sealed; and
 heated to a temperature of between about 100° C. and about 110° C. for a period of time between about 60 minutes and about 120 minutes. 
 
   
     
     
         5 . An article of manufacture, comprising:
 a container comprised of a material taken from the list of:   (a) aluminum,   (b) plastic, and   (c) glass;   packed with a mixture of about 3.5% by weight of polyoctyl-2-cyanoacrylate, about 100 ppm sulfur dioxide, and about 1000 ppm butylated hydroxyanisole (BHA), all dissolved in the balance percentage by weight of octyl-2-cyanoacrylate monomer, then sealed; and   the sealed container heated to a temperature of between about 100° C. and about 110° C. for a period of time between about 60 minutes and 120 minutes, establishing a sterile adhesive having a viscosity of in the range of about 400 centipoises to about 600 centipoises.