Hemostatic compositions

Abstract

The invention discloses a hemostatic composition comprising: a) a biocompatible polymer in particulate form suitable for use in hemostasis, and b) one hydrophilic polymeric component comprising reactive groups.

1 . A hemostatic composition comprising:
 a) a biocompatible polymer in particulate form suitable for use in hemostasis; and   b) one hydrophilic polymeric component comprising reactive groups.   
     
     
         2 . The hemostatic composition according to  claim 1 , wherein the biocompatible polymer and the hydrophilic polymeric component are present in paste form. 
     
     
         3 . The hemostatic composition according to  claim 1 , wherein said biocompatible polymer suitable for use in hemostasis contains a member selected from the group consisting of a protein, a polysaccharide, a biologic polymer, a non-biologic polymer, and derivatives and combinations thereof. 
     
     
         4 . The hemostatic composition according to  claim 1 , wherein the hydrophilic polymer component is a polyalkylene oxide polymer. 
     
     
         5 . The hemostatic composition according to  claim 1 , wherein said hydrophilic polymeric component with reactive groups is a polyethylene glycol (PEG). 
     
     
         6 . The hemostatic composition according to  claim 1 , further comprising a binder, wherein the binder contains or is a substance selected from the group consisting of glycerol, a derivative of glycerol, DMSO, ethanol, a polyethyleneglycol, a Poloxamer, and combinations thereof. 
     
     
         7 . The hemostatic composition according to  claim 1 , further comprising a binder, wherein the binder has a water content (% v/v) below 5%. 
     
     
         8 . A method of treating a patient, comprising administering to the patient a hemostatic composition according to  claim 1  for the treatment of an injury selected from the group consisting of a wound, a hemorrhage, a damaged tissue, a bleeding tissue, qne a bone defect. 
     
     
         9 . A kit for the treatment of an injury selected from the group consisting of a wound, a hemorrhage, a damaged tissue, and a bleeding tissue, comprising:
 a) a hemostatic composition according to  claim 1 ; and   b) instructions for use   
     
     
         10 . A method for producing a hemostatic composition according to  claim 1  comprising the step of mixing a biocompatible polymer suitable for use in hemostasis and one hydrophilic polymeric component comprising reactive groups with a binder wherein the reactivity of the polymeric component is retained. 
     
     
         11 . The hemostatic composition according to  claim 2 , wherein the biocompatible polymer and the hydrophilic polymeric component are present with a binder wherein the reactivity of the polymeric component is retained. 
     
     
         12 . The hemostatic composition according to  claim 2 , wherein the polyalkylene oxide polymer is a PEG comprising polymer. 
     
     
         13 . The hemostatic composition according to  claim 2 , wherein the polyalkylene oxide polymer is a multi-electrophilic polyalkylene oxide polymer. 
     
     
         14 . The hemostatic composition according to  claim 2 , wherein the polyalkylene oxide polymer is a multi-electrophilic PEG. 
     
     
         15 . The hemostatic composition according to  claim 2 , wherein the polyalkylene oxide polymer is pentaerythritolpoly(ethyleneglycol)ether tetrasuccinimidyl glutarate. 
     
     
         16 . The hemostatic composition according to  claim 5 , wherein the hydrophilic polymeric component with reactive groups is a polyethylene glycol (PEG) comprising two or more reactive groups selected from succinimidylesters (—CON(COCH 2 ) 2 ), aldehydes (—CHO) and isocyanates (—N═C═O). 
     
     
         17 . The hemostatic composition according to  claim 7 , wherein the binder has a water content (% v/v) below 2%. 
     
     
         18 . The hemostatic composition according to  claim 7 , wherein the binder has a water content (% v/v) below 1%. 
     
     
         19 . The method according to  claim 10 , wherein the mixing step comprises blending.