US2013060005A1PendingUtilityA1
Compositions and methods for inhibiting the interaction between cftr and cal
Est. expiryOct 22, 2028(~2.2 yrs left)· nominal 20-yr term from priority
A61P 3/00C07K 14/4703A61K 38/00A61K 38/10C07K 5/1013A61K 38/04A61P 11/00A61K 38/08
43
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Claims
Abstract
The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface.
Claims
exact text as granted — not AI-modified1 . A peptide comprising the sequence WQVTRV (SEQ ID NO:23).
2 . A peptide consisting of the sequence WQVTRV (SEQ ID NO:23).Join the waitlist — get patent alerts
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