Retinoid topical compositions and methods for treating skin conditions

Abstract

A topical pharmaceutical composition comprising tazarotene and one or more of an anti-inflammatory or anti-bacterial agent. Also provided is a method for treating skin conditions, such as acne utilizing the above topical pharmaceutical composition.

1 . A topical pharmaceutical composition for the treatment of acne, said composition comprising tazarotene and one or more of an anti-inflammatory or anti-bacterial agent. 
     
     
         2 . The topical pharmaceutical composition of  claim 1 , wherein tazarotene is present in an amount equal to or less than 10% w/w. 
     
     
         3 . The topical pharmaceutical composition of  claim 2 , wherein tazarotene is present in an amount of about 0.1% w/w. 
     
     
         4 . The topical pharmaceutical composition of  claim 1 , wherein said anti-inflammatory or anti-bacterial agent is an anti-acne agent. 
     
     
         5 . The topical pharmaceutical composition of  claim 1 , wherein said anti-inflammatory or anti-bacterial agent is clindamycin or dapsone. 
     
     
         6 . The topical pharmaceutical composition of  claim 5 , comprising dapsone in an amount equal to or less than 15% w/w. 
     
     
         7 . The topical pharmaceutical composition of  claim 6 , comprising dapsone in an amount equal to or less than 5% w/w. 
     
     
         8 . The topical pharmaceutical composition of  claim 1 , further comprising benzoyl peroxide in an amount equal to or less than 10% w/w. 
     
     
         9 . The topical pharmaceutical composition of  claim 8 , wherein the benzoyl peroxide is present in an amount equal to or less than 2.5% w/w. 
     
     
         10 . A combination product for the treatment of acne, said product comprising a first topical composition comprising tazarotene and a second topical composition comprising an anti-inflammatory or an anti-bacterial agent. 
     
     
         11 . The combination product of  claim 10 , wherein tazarotene is present in the first topical composition in an amount equal to or less than 10% w/w. 
     
     
         12 . The combination product of  claim 11 , wherein tazarotene is present in the first topical composition in an amount of about 0.1% w/w. 
     
     
         13 . The combination product of  claim 10 , wherein said anti-inflammatory or anti-bacterial agent of the second topical composition is an anti-acne agent. 
     
     
         14 . The combination product of  claim 13 , wherein said anti-inflammatory or anti-bacterial agent of the second topical composition is clindamycin or dapsone. 
     
     
         15 . The combination product of  claim 14 , wherein dapsone is present in the second topical composition in an amount equal to or less than 15% w/w. 
     
     
         16 . The combination product of  claim 15 , wherein the dapsone is present in the second topical composition in an amount equal to or less than 5% w/w. 
     
     
         17 . The combination product of  claim 13 , wherein the anti-inflammatory or anti-bacterial agent is benzoyl peroxide and is present in the second topical composition in an amount equal to or less than 10% w/w. 
     
     
         18 . The combination product of  claim 17 , wherein the benzoyl peroxide is present in the second composition in an amount equal to or less than 2.5% w/w. 
     
     
         19 . A method of treating acne in a patient in need thereof, said method comprising administering to said patient a topical pharmaceutical composition comprising tazarotene and an anti-inflammatory or anti-bacterial agent wherein said tazarotene, said anti-inflammatory agent and said anti-bacterial agent are present in a combined amount effective to treat acne in said patient. 
     
     
         20 . The method of  claim 19 , wherein tazarotene is present in an amount equal to or less than 10% w/w. 
     
     
         21 . The method of  claim 20 , wherein tazarotene is present in an amount of about 0.1% w/w. 
     
     
         22 . The method of  claim 19 , wherein said anti-inflammatory or anti-bacterial agent is an anti-acne agent. 
     
     
         23 . The method of  claim 22 , wherein said anti-inflammatory or anti-bacterial agent is clindamycin or dapsone. 
     
     
         24 . The method of  claim 23 , wherein said dapsone is present an amount equal to or less than 15% w/w. 
     
     
         25 . The method of  claim 24 , wherein dapsone is present an amount equal to or less than 5% w/w. 
     
     
         26 . The method of  claim 19 , wherein said anti-bacterial agent is benzoyl peroxide, and is present in an amount equal to or less than 10% w/w. 
     
     
         27 . The method of  claim 19 , wherein the benzoyl peroxide is present in an amount equlal to or less than 2.5% w/w. 
     
     
         28 . The method of  claim 19 , wherein said acne is acne vulgaris. 
     
     
         29 . The method of  claim 19 , wherein said acne is comedonal acne.