Method to mitigate injury from radiation exposure

Abstract

Mitigating radiation induced injury to a mammal that has been exposed to radiation by administering a pharmaceutically effective amount of a composition comprising at least one CXCR4 antagonist to the mammal.

1 . A method of mitigating radiation induced injury to a mammal that has been exposed to radiation, comprising the step of administering a pharmaceutically effective amount of a composition comprising at least one CXCR4 antagonist to the mammal. 
     
     
         2 . The method of  claim 1  wherein commencement of administration is effected at least 24 hours after exposure. 
     
     
         3 . The method of  claim 1  wherein commencement of administration is effected at least 48 hours after exposure. 
     
     
         4 . The method of  claim 1  wherein commencement of administration is effected at least 72 hours after exposure. 
     
     
         5 . The method of  claim 1  wherein commencement of administration is effected at least one week after exposure. 
     
     
         6 . The method of  claim 1  wherein commencement of administration is effected between 24 hours and one week after exposure. 
     
     
         7 . The method of  claim 1  wherein commencement of administration is effected between 48 hours and one week after exposure. 
     
     
         8 . The method of  claims 1 - 7  wherein the mammal is a human. 
     
     
         9 . The method of  claims 1 - 8  wherein the CXCR4 antagonist is AMD-3100. 
     
     
         10 . The method of  claims 1 - 9  wherein the CXCR4 antagonist is coadmistered with a granulocyte colony-stimulating factor. 
     
     
         11 . The method of  claims 1 - 10  wherein the method mitigates radiation induced injury to tissue. 
     
     
         12 . The method of  claim 11  wherein the method mitigates radiation induced injury to organ tissue. 
     
     
         13 . The method of  claim 12  wherein the method mitigates radiation induced injury to skin.