METHOD OF PRODUCING HIGH-CONCENTRATED TECHNETIUM-99m SOLUTION IN LARGE QUANTITIES

Abstract

A method of producing high concentrated 99m Tc solution has the steps of dissolving 99 MoO 3 pellet with alkali solution; extracting 99m Tc from the dissolved solution with ketone type organic solvent; separating an ketone type organic phase containing 99m Tc and an aqueous phase; adsorbing and concentrating the separated ketone type organic phase containing 99m Tc after removing impurities, through a basic alumina column for impurity removal and an acidic alumina column for adsorption and concentration connected continuously; and eluting 99m Tc from the acidic alumina column to which 99m Tc is adsorbed by physiological saline, wherein the alkali solution is 6M-NaOH solution or 6M-KOH solution.

1 . A method of producing high concentrated  99m Tc solution comprises the steps of:
 dissolving  99 MoO 3  pellet with alkali solution;   extracting  99m Tc from the dissolved solution with ketone type organic solvent;   separating an ketone type organic phase containing  99m Tc and an aqueous phase;   adsorbing and concentrating the separated ketone type organic phase containing  99m Tc after removing impurities, through a basic alumina column for impurity removal and an acidic alumina column for adsorption and concentration connected continuously; and   eluting  99m Tc from the acidic alumina column to which  99m Tc is adsorbed by physiological saline,   wherein said alkali solution is 6M-NaOH solution or 6M-KOH solution,   
     
     
         2 . The method according to  claim 1 , wherein an acid alumina prepared by processing alumina with uniform particle diameter in 0.1M-HNO 3  for 24 hours or more is used as alumina used for said acidic alumina column. 
     
     
         3 . The method according to  claim 1 , wherein a diameter of said acidic alumina column which adsorbs  99m Tc is set to the range of Φ10-14 mm. 
     
     
         4 . The method according to  claim 1 , wherein said ketone type organic solvent is methyl ethyl ketone solution. 
     
     
         5 . The method according to  claim 4 , wherein a diameter of said acidic alumina column which adsorbs  99m Tc is set to the range of Φ10-14 mm.