Genes involved in inflammatory bowel diseases and use thereof

Abstract

The invention concerns genes involved in inflammatory and/or immune diseases and some cancers, in particular intestinal cryptogenic inflammatory diseases, and proteins coded by said genes. The invention also concerns methods for diagnosing inflammatory diseases.

1 - 25 . (canceled) 
     
     
         26 . A purified or isolated nucleic acid probe, wherein said nucleic acid probe is specific for a variant nucleic acid sequence selected from the group consisting of SEQ ID NO:3 having a C to T mutation at nucleotide 16467, SEQ ID NO:3 having a G to C mutation at nucleotide 27059, and SEQ ID NO:3 having a C insertion at nucleotide 34296. 
     
     
         27 . The nucleic acid probe of  claim 26 , wherein said nucleic acid probe is specific for SEQ ID NO:3 having a C to T mutation at nucleotide 16467. 
     
     
         28 . The nucleic acid probe of  claim 26 , wherein said nucleic acid probe is specific for SEQ ID NO:3 having a G to C mutation at nucleotide 27059. 
     
     
         29 . The nucleic acid probe of  claim 26 , wherein said nucleic acid probe is specific for SEQ ID NO:3 having a C insertion at nucleotide 34296. 
     
     
         30 . The nucleic acid probe of  claim 26 , wherein said nucleic acid probe is about 15 to 30 nucleotides in length. 
     
     
         31 . The nucleic acid probe of  claim 26 , wherein said nucleic acid probe comprises a detectable label. 
     
     
         32 . The nucleic acid probe of  claim 31 , wherein said detectable label is selected from the group consisting of a radioactive isotope, a ligand, and a luminescent agent. 
     
     
         33 . The nucleic acid probe of  claim 32 , wherein said ligand is selected from the group consisting of biotin, avidin, streptavidin, dioxygenin, a hapten, and a dye. 
     
     
         34 . The nucleic acid probe of  claim 32 , wherein said luminescent agent is selected from the group consisting of a radioluminescent agent, a chemiluminescent agent, a bioluminescent agent, a fluorescent agent, and a phosphorescent agent. 
     
     
         35 . The nucleic acid probe of  claim 26 , wherein said nucleic acid probe is immobilized on a support. 
     
     
         36 . A kit comprising the nucleic acid probe of  claim 26 . 
     
     
         37 . The kit of  claim 36 , wherein said kit comprises nucleic acid probes specific for at least two of said variant nucleic acid sequences. 
     
     
         38 . The kit of  claim 36 , wherein said kit comprises nucleic acid probes specific for three of said variant nucleic acid sequences. 
     
     
         39 . A DNA chip comprising the nucleic acid probe of  claim 26 . 
     
     
         40 . The DNA chip of  claim 39 , wherein said DNA chip comprises nucleic acid probes specific for at least two of said variant nucleic acid sequences. 
     
     
         41 . The DNA chip of  claim 39 , wherein said DNA chip comprises nucleic acid probes specific for three of said variant nucleic acid sequences.